Streptococcal cysteine proteinase releases kinins: a virulence mechanism.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polycrylamide to nitrocellulose

1984 • 2,553 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Streptococcal M protein: molecular design and biological behavior

1989 • 820 citations

Bradykinin receptors: Pharmacological properties and biological roles

1992 • 462 citations

Aspects of Pathogenesis of Serious Group A Streptococcal Infections in Sweden, 1988-1989

1992 • 303 citations

Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

1993 • 254 citations

Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma.

1979 • 230 citations

A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin

1993 • 225 citations

Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor

1989 • 222 citations

Streptococcal Cysteine Proteinase Releases Biologically Active Fragments of Streptococcal Surface Proteins

1995 • 219 citations

A PROTEOLYTIC ENZYME PRODUCED BY GROUP A STREPTOCOCCI WITH SPECIAL REFERENCE TO ITS EFFECT ON THE TYPE-SPECIFIC M ANTIGEN

1945 • 211 citations

Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases

1986 • 209 citations

Are bacterial proteinases pathogenic factors?

1995 • 205 citations

Mechanism of action of the group A streptococcal C5a inactivator.

1985 • 184 citations

Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor

1990 • 149 citations

Assembly of contact-phase factors on the surface of the human neutrophil membrane

1994 • 132 citations

Purification and characterization of a potent 70-kDa thiol lysyl-proteinase (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen.

1993 • 125 citations

Vaccination with streptococcal extracellular cysteine protease (interleukin-1β convertase) protects mice against challenge with heterologous group A streptococci

1994 • 123 citations

Identification of an endothelial cell binding site on kininogen domain D3

1995 • 114 citations

Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.

1993 • 102 citations

Identification of an extracellular plasmin binding protein from nephritogenic streptococci.

1993 • 89 citations

Streptococcal Proteinase: the Zymogen to Enzyme Transformation

1965 • 89 citations

Isolation and characterization of erythrogenic toxins V. Communication: Identity of erythrogenic toxin type B and Streptococcal proteinase precursor

1983 • 89 citations

Human kininogens interact with M protein, a bacterial surface protein and virulence determinant

1995 • 83 citations

Flesh-Eating Bacteria: Not New, But Still Worrisome

1994 • 70 citations

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections

1991 • 68 citations

Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies interfering with their functional properties.

1993 • 64 citations

Proteinase-sensitive regions in the heavy chain of low molecular weight kininogen map to the inter-domain junctions.

1988 • 53 citations

The carboxyl terminus of bradykinin and amino terminus of the light chain of kininogens comprise an endothelial cell binding domain.

1994 • 51 citations

Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.

1994 • 50 citations

MYOCARDIAL NECROSIS PRODUCED IN ANIMALS BY MEANS OF CRYSTALLINE STREPTOCOCCAL PROTEINASE

1954 • 42 citations

[21] Human kininogens

1988 • 39 citations

Limited proteolysis of human low-molecular-mass kininogen by tissue kallikrein. Isolation and characterization of the heavy and the light chains

1985 • 31 citations

Novel Functions of the Kininogens

1987 • 31 citations

Effects of Bradykinin and Endothelin-1 on the Calcium Homeostasis of Mammalian Cells

1995 • 26 citations

Murine fibroblasts synthesize and secrete kininogen in response to cyclic-AMP, prostaglandin E2 and tumor necrosis factor

1995 • 14 citations

Intracellular form of streptococcal proteinase: A clue to a novel mechanism of secretion

1984 • 13 citations

[Measurements of pH values in vitro and in vivo in chronic tonsillitis].

1970 • 3 citations