Are bacterial proteinases pathogenic factors?

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene

1995 • 247 citations

Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.

1992 • 244 citations

Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases

1992 • 234 citations

Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor

1989 • 222 citations

Synthetic Inhibitors of Elastase

1994 • 207 citations

Activation of Hageman Factor and Prekallikrein and Generation of Kinin by Various Microbial Proteinases

1989 • 195 citations

Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.

1994 • 169 citations

Streptococcal C5a peptidase is a highly specific endopeptidase

1992 • 168 citations

The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.

1986 • 151 citations

Blocking Periodontal Disease Progression by Inhibiting Tissue‐Destructive Enzymes: A Potential Therapeutic Role for Tetracyclines and Their Chemically‐Modified Analogs

1993 • 149 citations

Proteases and their inhibitors in chronic inflammatory periodontal disease

1986 • 106 citations

Intracellular Proteinases in Microorganisms

1975 • 102 citations

Inactivation of key factors of the plasma proteinase cascade systems by Bacteroides gingivalis

1985 • 89 citations

Inhibition of C3 and IgG proteolysis enhances phagocytosis of Porphyromonas gingivalis.

1993 • 88 citations

Increased opsonization of a prtH-defective mutant of Porphyromonas gingivalis W83 is caused by reduced degradation of complement-derived opsonins.

1995 • 86 citations

Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureus

1992 • 80 citations

Degradation of protease inhibitors, immunoglobulins, and other serum proteins by Serratia protease and its toxicity to fibroblast in culture

1986 • 71 citations

Degradation of basement membranes by Pseudomonas aeruginosa elastase

1989 • 69 citations

Pathogenicity and virulence of black-pigmented Gram-negative anaerobes

1993 • 67 citations

Pathogenic potentials of bacterial proteases

1989 • 66 citations

Inactivation of chemotactic activity of C5a by the serratial 56-kilodalton protease

1990 • 56 citations

Effect of microbial and mite proteases on low and high molecular weight kininogens. Generation of kinin and inactivation of thiol protease inhibitory activity.

1993 • 49 citations

Internalization of serratial protease into cells as an enzyme-inhibitor complex with alpha 2-macroglobulin and regeneration of protease activity and cytotoxicity.

1987 • 47 citations

Effects of protease inhibitors on growth of Serratia marcescens and Pseudomonas aeruginosa

1991 • 28 citations

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