Persistent Binding of Ligands to the Aryl Hydrocarbon Receptor

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

2003 • 1,782 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

INDUCTION OF CYTOCHROME P4501A1

1999 • 1,124 citations

AH RECEPTOR SIGNALING PATHWAYS

1996 • 898 citations

Atom/Fragment Contribution Method for Estimating Octanol–Water Partition Coefficients

1995 • 846 citations

Principles of Drug Action: The Basis of Pharmacology.

1975 • 616 citations

Current Protocols in Toxicology

2001 • 549 citations

Ligand binding and activation of the Ah receptor

2002 • 479 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

1994 • 327 citations

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.

1974 • 293 citations

The role of chaperone proteins in the aryl hydrocarbon receptor core complex

2002 • 282 citations

The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation

2002 • 237 citations

A Novel Method for Measuring Membrane-Water Partition Coefficients of Hydrophobic Organic Chemicals: Comparison with 1-Octanol–Water Partitioning

1988 • 226 citations

Biological Basis for Risk Assessment of Dioxins and Related Compounds

1991 • 212 citations

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors inFundulus heteroclitus

2004 • 206 citations

Estradiol-binding kinetics of the activated and nonactivated estrogen receptor.

1977 • 191 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1996 • 164 citations

An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and β-naphthoflavone binding

2001 • 156 citations

Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole

1998 • 150 citations

Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

2006 • 149 citations

Use of 2-Azido-3-[¹²⁵I]iodo-7,8-dibromodibenzo-p-dioxin as a Probe to Determine the Relative Ligand Affinity of Human versus Mouse Aryl Hydrocarbon Receptor in Cultured Cells

2004 • 109 citations

Regulation of CYP1A1 by Indolo[3,2-b]carbazole in Murine Hepatoma Cells

1995 • 106 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1.

1994 • 97 citations

Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin.

1988 • 97 citations

Ligand-Dependent and Independent Modulation of Aryl Hydrocarbon Receptor Localization, Degradation, and Gene Regulation

2002 • 92 citations

Molecular Biology Of The Toxic Response

1999 • 91 citations

Different Structural Requirements of the Ligand Binding Domain of the Aryl Hydrocarbon Receptor for High- and Low-Affinity Ligand Binding and Receptor Activation

2004 • 86 citations

Carbaryl, a Carbamate Insecticide, Is a Ligand for the Hepatic Ah (Dioxin) Receptor

1998 • 80 citations

Evidence for the Ligand-Independent Activation of the AH Receptor

1995 • 78 citations

Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro cypia activity and polycyclic aromatic hydrocarbon‐derived embryonic deformities

2005 • 77 citations

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species

1986 • 70 citations

Ah receptor-dependent CYP1A induction by two carotenoids, canthaxanthin and β-apo-8″-carotenal, with no affinity for the TCDD binding site

1997 • 70 citations

Carbaryl InducesCYP1A1Gene Expression in HepG2 and HaCaT Cells but Is Not a Ligand of the Human Hepatic Ah Receptor

1997 • 69 citations

The Transactivation Domain of the Ah Receptor Is a Key Determinant of Cellular Localization and Ligand-Independent Nucleocytoplasmic Shuttling Properties

2005 • 64 citations

Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer

1992 • 64 citations

A model for recognition of polychlorinated dibenzo‐p‐dioxins by the aryl hydrocarbon receptor

2002 • 60 citations

Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin

1993 • 59 citations

Ligand-dependent and -independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models

2006 • 54 citations

Redefining the Role of the Endogenous XAP2 and C-terminal hsp70-interacting Protein on the Endogenous Ah Receptors Expressed in Mouse and Rat Cell Lines

2005 • 53 citations

Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.

1992 • 51 citations

Analysis of the Aryl Hydrocarbon Receptor (<scp>Ah</scp><scp>R</scp>) Signal Transduction Pathway

2002 • 50 citations

Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor

1999 • 47 citations

Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor

1998 • 45 citations

Analysis of Binding of [³H]Estradiol to the Cytosol Fraction of Rat Pancreas: Comparison with Sites in the Cytosol of Uterus*

1983 • 39 citations

Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners

1987 • 39 citations

Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues.

2000 • 35 citations

The hepatic Ah receptor for 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Species differences in subunit dissociation

1990 • 33 citations

Kinetic models for association of 2,3,7,8-tetrachlorodibenzo-p-dioxin with the Ah receptor

1988 • 33 citations

Additive Binding of Polychlorinated Biphenyls and 2,3,7,8-Tetrachlorodibenzo-p-dioxin to the Murine Hepatic Ah Receptor

1994 • 28 citations

Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1987 • 27 citations

Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein

1987 • 21 citations

Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-Labeled ligand for diagnostic imaging

2002 • 17 citations

The stability of dioxin-receptor ligands influences cytochrome P450IA1 expression in human keratinocytes

1992 • 14 citations

Heterogeneity of rat hepatic Ah Receptor: Identification of two receptor forms which differ in their biochemical properties

1992 • 10 citations

Comparison of the induction of a 4S ?-naphthoflavone-binding protein, cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in ?-naphthoflavone-treated rats

2004 • 7 citations

The Role of Ligand-Binding as a Determinant of the Structure and Activation of the Estrogen Receptor

1979 • 5 citations

Characterization of progesterone binding to nuclear receptors in rat placenta

1986 • 4 citations