Cdk5/p35 Regulates Neurotransmitter Release through Phosphorylation and Downregulation of P/Q-Type Voltage-Dependent Calcium Channel Activity

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

2016 • 4,824 citations

Short-Term Synaptic Plasticity

2002 • 4,618 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Short-Term Synaptic Plasticity

1989 • 1,464 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 920 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

1988 • 912 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1994 • 625 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels

1995 • 590 citations

Biochemical properties and subcellular distribution of an N-type calcium hannel α1 subunit

1992 • 587 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

2000 • 482 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus

1999 • 404 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

Neurotransmitter release — four years of SNARE complexes

1997 • 400 citations

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

1996 • 390 citations

Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release

1998 • 388 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

1995 • 342 citations

Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.

1996 • 321 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 293 citations

Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin

1999 • 287 citations

Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions

1996 • 243 citations

Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus

1996 • 199 citations

Neuronal cdc2-like kinase

1995 • 179 citations

Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin

1999 • 168 citations

Regulation of Munc-18/Syntaxin 1A Interaction by Cyclin-dependent Kinase 5 in Nerve Endings

1998 • 160 citations

Phosphorylation of the Synaptic Protein Interaction Site on N-type Calcium Channels Inhibits Interactions with SNARE Proteins

1997 • 154 citations

Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by cdk5 and cdc2

2001 • 129 citations

Ca ²⁺ -dependent and -independent interactions of the isoforms of the α _1A subunit of brain Ca ²⁺ channels with presynaptic SNARE proteins

1997 • 122 citations

Nonuniform Distribution of Ca²⁺Channel Subtypes on Presynaptic Terminals of Excitatory Synapses in Hippocampal Cultures

1997 • 101 citations

Interaction of Cyclin-dependent Kinase 5 (Cdk5) and Neuronal Cdk5 Activator in Bovine Brain

1996 • 94 citations

Cdk5/p25nck5a interaction with synaptic proteins in bovine brain

2000 • 60 citations

Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus

1996 • 57 citations

Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain

1996 • 53 citations

Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis.

1998 • 47 citations

Immunosuppressant FK506 prevents mossy fiber sprouting induced by kindling stimulation

1996 • 24 citations

Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35nck5a) in the developing rat cerebellum

1996 • 22 citations

Involvement of Cyclin-Dependent Kinase 5/p35nck5a in the Synaptic Reorganization of Rat Hippocampus during Kindling Progression.

2000 • 9 citations

Measured increase in intracellular Ca2+ during stimulated release of endogenous glutamate from human cerebrocortical synaptosomes

1999 • 8 citations