Structure-function relationships of cation binding in the Na+/K+-ATPase

Ionic channels of excitable membranes

1985 • 7,199 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

The influence of some cations on an adenosine triphosphatase from peripheral nerves

1957 • 2,211 citations

The Sodium Pump

1975 • 969 citations

Isozymes of the Na+/K+-ATPase

1989 • 955 citations

Biochemical Aspects of Active Transport

1967 • 835 citations

Potassium channels as multi-ion single-file pores.

1978 • 816 citations

Further investigations on a Mg++ + Na+-activated adenosintriphosphatase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane

1960 • 799 citations

Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

1985 • 762 citations

Molecular cloning of three distinct forms of the Na+,K+-ATPase .alpha.-subunit from rat brain

1986 • 688 citations

Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

1979 • 598 citations

The Na,K-ATPase

1992 • 552 citations

Mechanism of the Na+, K+ pump protein structure and conformations of the pure

1982 • 500 citations

Flexibility of an Active Center in Sodium-Plus-Potassium Adenosine Triphosphatase

1969 • 476 citations

Transport adenosine triphosphatases: properties and functions.

1981 • 474 citations

Preparation from mammallian brain and kidney of the enzyme system involved in active transport of Na+ and K+

1962 • 441 citations

Molecular Genetics of Na,K-ATPase

1990 • 411 citations

The effect of catecholamines on Na—K transport and membrane potential in rat soleus muscle

1977 • 403 citations

Structure-function relationships in the sodium-potassium ATPase .alpha. subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

1988 • 403 citations

Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.

1988 • 379 citations

Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence

1985 • 375 citations

The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase.

1990 • 358 citations

The sodium pump needs its β subunit

1990 • 343 citations

Structural basis for E1–E2 conformational transitions in Na, K-pump and Ca-pump proteins

1988 • 338 citations

Purification and characterization of (Na+, K+)-ATPase. V. Conformational changes in the enzyme. Transitions between the Na-form and the K-form studied with tryptic digestion as a tool

1975 • 328 citations

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

1992 • 327 citations

Electrogenic Ion Pumps

1982 • 314 citations

Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells.

1991 • 308 citations

[1] Overview: The Na,K-pump

1988 • 302 citations

Structure-Function Relationship of Na,K-ATPase

1991 • 294 citations

[Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes.

1989 • 254 citations

Molecular characterization and expression of the (Na+ + K+)-ATPase alpha-subunit in Drosophila melanogaster.

1989 • 246 citations

Voltage dependence of Na/K pump current in isolated heart cells

1985 • 240 citations

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

1987 • 231 citations

Voltage dependence of Na translocation by the Na/K pump

1986 • 230 citations

A role for the beta-subunit in the expression of functional Na+-K+-ATPase in Xenopus oocytes

1989 • 228 citations

Na,K-ATPase: Isoform structure, function, and expression

1992 • 213 citations

The amino acid sequence of a fluorescein-labeled peptide from the active site of (Na,K)-ATPase.

1984 • 212 citations

Pig kidney Na⁺,K⁺‐ATPase

1986 • 207 citations

OCCLUDED CATIONS IN ACTIVE TRANSPORT

1990 • 205 citations

Chemical modification as an approach to elucidation of sodium pump structure-function relations

1990 • 203 citations

Active transport of sodium and potassium ions by the sodium and potassium ion-activated adenosine triphosphatase from renal medulla. Reconstitution of the purified enzyme into a well defined in vitro transport system.

1977 • 194 citations

Voltage Dependence of the Na-K Pump

1988 • 191 citations

Evidence for an Aspartyl Phosphate Residue at the Active Site of Sodium and Potassium Ion Transport Adenosine Triphosphatase

1973 • 183 citations

Extracellular Access to the Na,K Pump: Pathway Similar to Ion Channel

1993 • 182 citations

Stoichiometry and voltage dependence of the sodium pump in voltage-clamped, internally dialyzed squid giant axon.

1989 • 171 citations

Insulin affects the sodium affinity of the rat adipocyte (Na+,K+)-ATPase.

1985 • 164 citations

Electrogenic transport. Fundamental principles and physiological implications.

1984 • 163 citations

Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump.

1992 • 159 citations

Structure-function studies of Na,K-ATPase. Site-directed mutagenesis of the border residues from the H1-H2 extracellular domain of the alpha subunit.

1990 • 159 citations

Extensive digestion of Na+,K(+)-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites.

1992 • 157 citations

The sodium pump : recent developments

1991 • 151 citations

A negative slope in the current-voltage relationship of the Na+/K+ pump inXenopus oocytes produced by reduction of external [K+]

1991 • 143 citations

Regulation of the (Na+ + K+)-ATPase in cultured chick skeletal muscle. Modulation of expression by the demand for ion transport.

1986 • 140 citations

Primary Structure of the α-Subunit of Human Na, K-ATPase Deduced from cDNA Sequence1

1986 • 136 citations

Proteolytic fragmentation of the catalytic subunit of the sodium and potassium adenosine triphosphatase. Alignment of tryptic and chymotryptic fragments and location of sites labeled with ATP and iodoacetate

1979 • 129 citations

Enzymatic properties of separated isozymes of the Na,K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry.

1985 • 127 citations

Molecular basis for the insensitivity of the Monarch (Danaus plexippus) to cardiac glycosides

1992 • 127 citations

Primary structure of the β‐subunit of Torpedo californica (Na⁺ + K⁺)‐ATPase deduced from the cDNA sequence

1986 • 125 citations

Rapid release of 42K and 86Rb from an occluded state of the Na,K-pump in the presence of ATP or ADP.

1987 • 123 citations

Charge translocation by the Na,K-pump: II. Ion binding and release at the extracellular face

1991 • 122 citations

Voltage dependence of the rheogenic Na+/K+ ATPase in the membrane of oocytes ofXenopus laevis

1986 • 121 citations

Tryptic and chymotryptic cleavage sites in sequence of α-subunit of (Na+ + K+)-ATPase from outer medulla of mammalian kidney

1986 • 121 citations

Charge translocation by the Na,K-pump: I. Kinetics of local field changes studied by time-resolved fluorescence measurements

1991 • 121 citations

Activation of protein kinase C by phorbol ester induces downregulation of the Na+/K+-ATPase in oocytes ofXenopus laevis

1990 • 120 citations

The effect of membrane potential on the mammalian sodium‐potassium pump reconstituted into phospholipid vesicles.

1987 • 118 citations

Phosphorylation of Na,K-ATPase alpha-subunits in microsomes and in homogenates of Xenopus oocytes resulting from the stimulation of protein kinase A and protein kinase C.

1992 • 114 citations

Rapid release of 42K or 86Rb from two distinct transport sites on the Na,K-pump in the presence of Pi or vanadate.

1987 • 110 citations

Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution

1990 • 109 citations

Charge movement by the Na/K pump in Xenopus oocytes.

1993 • 109 citations

Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

1992 • 109 citations

Electrogenic ion pumps

1992 • 107 citations

Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells

1993 • 106 citations

The role of the sodium pump in the effects of potassium‐depleted solutions on mammalian cardiac muscle

1979 • 104 citations

The Na/K Pump of Cardiac Cells

1984 • 104 citations

The hormone-sensitive hepatic Na+-pump. Evidence for regulation by diacylglycerol and tumor promoters.

1986 • 102 citations

Kinetics of phosphorylation of Na+K+-ATPase by protein kinase C

1990 • 95 citations

The adhesion molecule on glia (AMOG/beta 2) and alpha 1 subunits assemble to functional sodium pumps in Xenopus oocytes.

1992 • 92 citations

Evidence for the organization of the transmembrane segments of (Na,K)-ATPase based on labeling lipid-embedded and surface domains of the alpha-subunit.

1982 • 88 citations

Site-directed Mutagenesis of a Conserved, Extracellular Aspartic Acid Residue Affects the Ouabain Sensitivity of Sheep Na,K-ATPase

1989 • 86 citations

The Na,K-ATPase beta 2 subunit is expressed in rat brain and copurifies with Na,K-ATPase activity.

1990 • 84 citations

Large scale partial purification and molecular and kinetic properties of the (Na + K)-activated adenosine triphosphatase from Artemia salina nauplii

1978 • 84 citations

The amino acid sequence of the fluorescein isothiocyanate reactive site of lamb and rat kidney Na+- and K+-dependent ATPase

1984 • 81 citations

Na+/K+-ATPase regulation by neurotransmitters

1992 • 74 citations

Downregulation of surface sodium pumps by endocytosis during meiotic maturation of Xenopus laevis oocytes

1990 • 72 citations

Location of Asn831 of the alpha chain of Na/K-ATPase at the cytoplasmic surface. Implication for topological models.

1993 • 71 citations

Family of human Na⁺,K⁺‐ATPase genes Structure of the gene for the catalytic subunit (αIII‐form) and its relationship with structural features of the protein

1988 • 70 citations

Fast charge translocations associated with partial reactions of the Na,K-pump: II. Microscopic analysis of transient currents

1987 • 70 citations

Molecular cloning of the Na,K‐ATPase α‐subunit in developing brine shrimp and sequence comparison with higher organisms

1989 • 66 citations

Topology of Na⁺,K⁺‐ATPase Identification of the extra‐ and intracellular hydrophilic loops of the catalytic subunit by specific antibodies

1988 • 66 citations

Native (Na-+ + K-+)-dependent adenosine triphosphatase has two trypsin-sensitive sites.

1975 • 65 citations

Organ Specificity of Rat Sodium- and Potassium-Activated Adenosine Triphosphatase1

1979 • 64 citations

Site-directed mutagenesis of a predicted cation binding site of sodium-potassium ATPase

1993 • 62 citations

Electrical potential accelerates the E1P(Na)----E2P conformational transition of (Na,K)-ATPase in reconstituted vesicles.

1986 • 61 citations

Regulation of endogenous and expressed Na+/K+ pumps in Xenopus oocytes by membrane potential and stimulation of protein kinases

1992 • 60 citations

Substitution of transmembrane residues with hydrogen-bonding potential in the .alpha. subunit of sodium-potassium ATPase reveals alterations in ouabain sensitivity

1993 • 60 citations

Current generated by backward-running electrogenic Na pump in squid giant axons

1984 • 60 citations

Stimulation of the Na+/K+ pump by external [K+] is regulated by voltage-dependent gating.

1991 • 59 citations

Na,K-ATPase extracellular surface probed with a monoclonal antibody that enhances ouabain binding.

1992 • 59 citations

Inactivation of Rb+ and Na+ occlusion on (Na+,K+)-ATPase by modification of carboxyl groups.

1988 • 57 citations

Site-directed mutagenesis of Asp-376, the catalytic phosphorylation site, and Lys-507, the putative ATP-binding site, of the α-subunit of Torpedo californica

1990 • 56 citations

".gamma. Subunit" of sodium-potassium-ATPase, a small, amphiphilic protein with a unique amino acid sequence

1987 • 56 citations

Any of several lysines can react with 5'-isothiocyanatofluorescein to inactivate sodium and potassium ion activated adenosinetriphosphatase

1989 • 55 citations

Epitope mapping by amino‐acid‐sequence‐specific antibodies reveals that both ends of the α subunit of Na⁺/K⁺‐ATPase are located on the cytoplasmic side of the membrane

1991 • 55 citations

Phosphorylated intermediates of Na,K-ATPase proteoliposomes controlled by bilayer cholesterol. Interaction with cardiac steroid.

1987 • 54 citations

Functional consequences of alterations to Pro³²⁸ and Leu³³² located in the 4th transmembrane segment of the α‐subunit of the rat kidney Na⁺,K⁺‐ATPase

1992 • 52 citations

Dependence of Na+ pump current on external monovalent cations and membrane potential in rabbit cardiac Purkinje cells.

1991 • 51 citations

Evidence for essential carboxyls in the cation-binding domain of the Na,K-ATPase

1991 • 50 citations

Evidence for the ordered release of rubidium ions occluded within the Na,K‐ATPase of mammalian kidney.

1985 • 50 citations

Voltage dependence of Na/K pump current inXenopus oocytes

1988 • 49 citations

Electrogenic and electroneutral transport modes of renal Na/K ATPase reconstituted into proteoliposomes

1990 • 47 citations

Lysine 480 is an essential residue in the putative ATP site of lamb kidney (Na,K)-ATPase. Identification of the pyridoxal 5'-diphospho-5'-adenosine and pyridoxal phosphate reactive residue.

1990 • 45 citations

Fluorescence study on cardiac glycoside binding to the Na,K‐pump Ouabain binding is associated with movement of electrical charge

1992 • 45 citations

The dependence of sodium pump current on internal Na concentration and membrane potential in cardioballs from sheep Purkinje fibres

1989 • 45 citations

Voltage Dependence Of The Na-K Pump

1988 • 40 citations

Voltage-dependent inhibition of the sodium pump by external sodium: Species differences and possible role of the N-terminus of the ?-subunit

1993 • 38 citations

Structure of the α₁ subunit of horse Na,K‐ATPase gene

1989 • 38 citations

Functional expression of N‐terminal truncated α‐subunits of Na,K‐ATPase in Xenopus laevis oocytes

1991 • 37 citations

Structural aspects of the gastric H,K-ATPase

1992 • 35 citations

Sodium and Potassium ATPase of the Teleost FishCatostomus commersoni.Sequence, Protein Structure and Evolutionary Conservation of the α-Subunit

1991 • 34 citations

Advances in Na⁺,K⁺‐ATPase studies: from protein to gene and back to protein

1989 • 32 citations

Purification and characterization of (Na+ + K+)-ATPase. VIII. Altered Na+: K+ transport ratio in vesicles reconstituted with purified (Na+ + K+)-ATPase that has been selectively modified with trypsin in presence of NaCl

1979 • 30 citations

Characteristics of the Na+/K+-ATPase from Torpedo californica expressed in Xenopus oocytes: A combination of tracer flux measurements with electrophysiological measurements

1988 • 30 citations

Phosphorylation of the Na,K-ATPase by Ca,phospholipid-dependent andcAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca,phospholipid-dependent protein kinase

1993 • 28 citations

Two-dimensional crystalline arrays of Na,K-ATPase with new subunit interactions induced by cobalt-tetrammine-ATP

1989 • 28 citations

Thalamic nociceptive mechanisms in cats, influenced by central conditioning stimuli

1992 • 27 citations

Complete purification of two identical Na⁺ ‐pump inhibitors isolated from bovine hypothalamus and hypophysis

1990 • 26 citations

Evolution of the Na,K- and H,K-ATPase β subunit gene family: Structure of the murine Na,K-ATPase β2 subunit gene

1991 • 26 citations

Na+ pump current‐voltage relationships of rabbit cardiac Purkinje cells in Na(+)‐free solution.

1993 • 24 citations

The effects of membrane potential on active and passive sodium transport in Xenopus oocytes.

1987 • 24 citations

Isoforms of Na,K-ATPase inArtemia salina: II. Tissue distribution and kinetic characterization

1989 • 24 citations

Anomalies in the electrophoretic resolution of Na+/K+-ATPase catalytic subunit isoforms reveal unusual protein—detergent interactions

1990 • 23 citations

Identification of cysteine residues in lamb kidney (Na,K)-ATPase essential for ouabain binding.

1991 • 22 citations

Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase.

1992 • 21 citations

Voltage-dependent stimulation of Na+/K+-pump current by external cations: selectivity of different K+ congeners

1992 • 21 citations

Transmembrane organization of the Na+,K(+)-ATPase molecule.

1992 • 20 citations

Calcium-mobilizing hormones and phorbol myristate acetate mediate heterologous desensitization of the hormone-sensitive hepatic Na+/K+ pump

1987 • 20 citations

Three-dimensional structure of Na,K-ATPase determined from membrane crystals induced by cobalt-tetrammine-ATP

1992 • 20 citations

Ouabain sensitivity of a chimeric α subunit (Torpedo/rat) of the (NA,K)ATPase expressed in Xenopus oocyte

1988 • 19 citations

Immunochemical evidence that the FITC-labeling site on Na+,K+-ATPase is not the ATP binding site

1987 • 18 citations

Digitalis-like properties of an inhibitor of the pump in human cerebrospinal fluid

1989 • 18 citations

Ouabain — a link in the genesis of high blood pressure

1992 • 16 citations

Phosphorylation of a Kidney Preparation of Na,K-ATPase by the Catalytic Subunit of cAMP-Dependent Protein Kinase

1983 • 15 citations

A monosaccharide is bound to the sodium-pump .alpha.-subunit

1992 • 14 citations

Two Isoenzymes of Na⁺, K⁺‐ATPase Have Different Kinetics of K⁺ Dephosphorylation in Normal Cat and Human Brain Cortex

1990 • 14 citations

Inactivation of the Na,K‐ATPase by modification of Lys‐501 with 4‐acetamido‐4′‐isothiocyanatostilbene‐2,2′‐disulfonic acid (SITS)

1992 • 14 citations

Regulation of the abundance of sodium pumps in isolated animal cells

1990 • 13 citations

Anomalous mobilities of Na,K-ATPase α subunit isoforms in SDS-PAGE: identification by N-terminal sequencing

1991 • 13 citations

Coexistence of different forms ofNa,K‐ATPase in two‐dimensional membrane crystals

1990 • 12 citations

Instructions to authors

1992 • 12 citations

Purification and Characterization of Specific Endogenous Ouabainlike Substance from Bovine Adrenal

1988 • 12 citations

A Na pump inhibitor from bovine posterior pituitary: Purification, structure determination and its cardiovascular effect in rat

1992 • 10 citations

Phosphorylation of two isozymes of (Na+ + K+)-ATPase by inorganic phosphate

1987 • 9 citations

Purification of a Na+K+ ATPase inhibitor from borderline hypertensives' plasma

1990 • 8 citations

Origin of the γ polypeptide of the Na+/K+-ATPase

1988 • 7 citations

Molecular isoforms of the sodium pump in brain.

1988 • 1 citations