Virus inactivation in a proportion of human T-cell leukaemia virus type I-infected T-cell clones arises through naturally occurring mutations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I Infection

1993 • 320 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

Direct visualization of antigen-specific T cells: HTLV-1 Tax11–19- specific CD8⁺T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

1998 • 237 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Genomic Evolution, Patterns of Global Dissemination, and Interspecies Transmission of Human and Simian T-cell Leukemia/Lymphotropic Viruses

1999 • 220 citations

Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I

1992 • 217 citations

Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia

1989 • 204 citations

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

1992 • 192 citations

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.

1990 • 189 citations

Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.

1989 • 188 citations

Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

1993 • 180 citations

Molecular Cloning and Complete Nucleotide Sequence of an Adult T Cell Leukaemia Virus/Human T Cell Leukaemia Virus Type I (ATLV/HTLV-I) Isolate of Caribbean Origin: Relationship to Other Members of the ATLV/HTLV-I Subgroup

1988 • 179 citations

Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions

1993 • 173 citations

Polymerase chain reaction analysis of defective human T-cell leukemia virus type I proviral genomes in leukemic cells of patients with adult T-cell leukemia

1991 • 114 citations

Nucleotide Sequence Analysis of Isolates of Human T-Lymphotropic Virus Type 1 of Diverse Geographical Origins

1991 • 108 citations

Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients

1991 • 107 citations

Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously

1994 • 106 citations

The indirect association of human T-cell leukemia virus tax protein with DNA results in transcriptional activation

1991 • 97 citations

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

1995 • 94 citations

T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.

1992 • 91 citations

Defective provirus form of human T-cell leukemia virus type I in adult T-cell leukemia/lymphoma: clinicopathological features.

1991 • 90 citations

The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis

1994 • 89 citations

Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis

1990 • 82 citations

Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs

1990 • 79 citations

Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange

1992 • 75 citations

Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I

1991 • 75 citations

Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.

1992 • 67 citations

Variable Immortalizing Potential and Frequent Virus Latency in Blood-Derived T-Cell Clones Infected With Human T-Cell Leukemia Virus Type I

1997 • 58 citations

Definition of a minimal activation domain in human T-cell leukemia virus type I Tax

1995 • 58 citations

Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes

1996 • 53 citations

Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy

1995 • 45 citations

Regional specificity of HTLV-I pro viral integration in the human genome

1994 • 41 citations

Cellular factors involved in transcription and Tax-mediated trans-activation directed by the TGACGT motifs in human T-cell leukemia virus type I promoter

1990 • 37 citations

Multiple Arginine Residues within the Basic Domain of HTLV-I Rex Are Required for Specific RNA Binding and Function

1993 • 30 citations

Sequences involved in the dimerisation of human T cell leukaemia virus type-1 RNA

1996 • 23 citations

Multiple targets of HTLV-1 for dysregulation of host cells

1996 • 18 citations

An HTLV-I Transgenic Mouse Model: Role of the Tax Gene in Pathogenesis in Multiple Organ Systems

1990 • 17 citations

cDNA sequencing confirms HTLV-I expression in adult T-cell leukemia/lymphoma and different sequence variations in vivo and in vitro.

1992 • 10 citations

Chromosomal localization of HTLV-1 viral integration sites using in situ hybridization: detection of a novel IL2R fragment

1992 • 9 citations

Differential Tax Expression in HTLV Type I-Infected Asymptomatic Carriers

1995 • 5 citations