Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells

1991 • 371 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

Revisiting and revising suppressor T cells

1992 • 256 citations

Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1‐ but not type 2‐associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats

1993 • 168 citations

T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.

1993 • 158 citations

Stigma Variations: Observations on Suppressor T Cells and Leprosy

1992 • 155 citations

Interferon: a cytotoxic T lymphocyte differentiation signal

1986 • 119 citations

Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.

1992 • 117 citations

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.

1990 • 109 citations

Selective differentiation of CD4+ T helper cell subsets

1993 • 104 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania major.

1993 • 62 citations

Induction of TH1- and TH2-associated cytokine mRNA in mouse bladder following intravesical growth of the murine bladder tumor MB49 and BCG immunotherapy

1994 • 56 citations

Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes.

1989 • 49 citations

Molecular regulation of human interleukin 2 and T-cell function by interleukin 4.

1993 • 35 citations

Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. II. Differential effects of IL-6 on the helper cell-independent generation of CTL from CD8+ precursor subpopulations.

1993 • 19 citations

Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. I. Differential helper cell requirement for the generation of cytotoxic effector cells from CD8+ precursor subpopulations.

1992 • 11 citations

Human Naive T Cells Are Preferentially Stimulated by Crosslinking of CD3 and CD45RA with Monoclonal Antibodies

1993 • 10 citations