5-HT3 receptor antagonists and anxiety; a preclinical and clinical review

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

1980 • 1,340 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

1985 • 845 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Animal models for the study of anti-anxiety agents: A review

1985 • 457 citations

Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems

1991 • 444 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Conditioned defensive burying: A new paradigm for the study of anxiolytic agents

1981 • 425 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

1993 • 369 citations

The structure of ion channels in membranes of excitable cells

1989 • 368 citations

Burying as a defensive response in rats.

1978 • 358 citations

Effects of the 5‐HT₃ receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

1987 • 354 citations

Burying as a defensive response in rats

1978 • 353 citations

The potential anxiolytic activity of GR38032F, a 5‐HT₃‐receptor antagonist

1988 • 332 citations

Buspirone

1986 • 330 citations

Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm.

1986 • 309 citations

Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice

1986 • 287 citations

Functional aspects of ultrasound production by infant albino rats (Rattus norvegicus)

1972 • 284 citations

Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics

1995 • 276 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Diazepam and flurazepam: Effects on conditioned fear as measured with the potentiated startle paradigm

1979 • 267 citations

Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm

1979 • 263 citations

Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm.

1986 • 261 citations

Neuropharmacology of Serotonin

1986 • 251 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

Animal Models in Psychopharmacology

1991 • 216 citations

5‐HT₃ receptors

1990 • 205 citations

Behavioural Pharmacology of 5-HT

1990 • 203 citations

Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives.

1990 • 196 citations

5-Ht1a Agonists, 5-Ht3 Antagonists and Benzodiazepines: Their Comparative Behavioural Pharmacology

1991 • 194 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

1990 • 190 citations

Risk Assessment Behaviour: Evaluation of Utility in the Study of 5-HT-Related Drugs in the Rat Elevated Plus-Maze Test

1997 • 188 citations

Effects of 5‐HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents

1991 • 179 citations

Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

1995 • 179 citations

Benzodiazepines as appetite-enhancing compounds

1980 • 178 citations

Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs

1993 • 178 citations

Animal Models in Psychopharmacology

1991 • 175 citations

Ondansetron

1996 • 173 citations

Zacopride: anxiolytic profile in rodent and primate models of anxiety

1988 • 170 citations

Evaluation of a rapid technique for detecting minor tranquilizers

1971 • 169 citations

The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice

1993 • 168 citations

8-OH-DPAT-induced hyperphagia: Its neural basis and possible therapeutic relevance

1986 • 167 citations

Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety

1993 • 159 citations

Behavioural Pharmacology of 5-HT

1989 • 158 citations

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

1987 • 157 citations

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

1987 • 156 citations

Stress-induced hyperthermia in mice: A methodological study

1994 • 154 citations

A model to measure anticipatory anxiety in mice?

1989 • 152 citations

Blockade of neuronal tryptamine receptors by metoclopramide

1978 • 148 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

Central and peripheral 5-HT3 receptors

1992 • 137 citations

Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety

1989 • 136 citations

Animal Models for Anxiety and Response to Serotonergic Drugs

1989 • 135 citations

Ultrastructure of the 5‐Hydroxytryptamine₃ Receptor

1995 • 132 citations

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

1991 • 127 citations

A new method for rapid screening of minor tranquillizers in mice

1968 • 124 citations

Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs

1995 • 121 citations

Pharmacological validation of a novel animal model of anticipatory anxiety in mice

1990 • 120 citations

Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

1995 • 117 citations

Stress-induced hyperthermia as a putative anxiety model

1995 • 112 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse

1990 • 108 citations

Effects of serotonergic agents on isolation-induced aggression

1991 • 107 citations

Blockade of serotonin receptors on autonomic neurones by (−)-cocaine and some related compounds

1979 • 103 citations

The infant rat separation paradigm: a novel test for novel anxiolytics

1991 • 103 citations

Blockade of the discriminative stimulus effects of ethanol with 5-HT3 receptor antagonists

1991 • 103 citations

Temporal patterning of ultrasonic distress calls in the adult rat: effects of morphine and benzodiazepines

1989 • 100 citations

Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes.

1989 • 99 citations

The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test

1998 • 97 citations

The Non-Antiemetic Uses of Serotonin 5-HT3 Receptor Antagonists

1997 • 97 citations

Sites of action of ondansetron to inhibit withdrawal from drugs of abuse

1990 • 96 citations

Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

1988 • 95 citations

Ultrasonic vocalizations in rat pups: effects of serotonergic ligands

1998 • 94 citations

Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice

1989 • 94 citations

5-Hydroxytryptamine-3 Receptor Antagonists

1993 • 94 citations

Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines

1988 • 93 citations

Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

1988 • 93 citations

Granisetron

1994 • 92 citations

Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?

1991 • 91 citations

Predictive validity of the potentiated startle response as a behavioral model for anxiolytic drugs

1995 • 90 citations

Core temperature: Some shortcomings of rectal temperature measurements

1977 • 88 citations

Withdrawal from oral cocaine in rats: ultrasonic vocalizations and tactile startle

1996 • 86 citations

Tropisetron

1993 • 86 citations

Ultrasounds during morphine withdrawal in rats

1991 • 85 citations

Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists

1991 • 84 citations

Serotonin 5-HT3 and 5-HT4 receptor antagonists

1997 • 83 citations

The discriminative stimulus effects of cocaine in pigeons.

1993 • 82 citations

Benzodiazepine ligands, nociception and ?defeat? analgesia in male mice

1987 • 82 citations

Behavioural pharmacology of 5-HT3 receptor ligands

1992 • 82 citations

Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.

1986 • 81 citations

A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder

1993 • 81 citations

Evidence that central 5‐hydroxytryptaminergic neurones are involved in the anxiolytic activity of buspirone

1989 • 79 citations

One-trial learning in the domestic rat.

1950 • 78 citations

Modulation of the brain aversive system by gabaregic and serotonergic mechanisms

1986 • 76 citations

Diazepam and gepirone selectively attenuate either 20–32 or 32–64 kHz ultrasonic vocalizations during aggressive encounters

1993 • 74 citations

Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors

1989 • 74 citations

The (S)-isomer of [3H]zacopride labels 5-HT3 receptors with high affinity in rat brain

1990 • 73 citations

Acute non-opioid analgesia in defeated male mice

1986 • 69 citations

Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region

1982 • 69 citations

Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms

1990 • 67 citations

Failure of ondansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat

1992 • 66 citations

The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety

1993 • 66 citations

Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats

1993 • 63 citations

Characterization of the Discriminative Stimulus Properties Induced by 5‐HT₁ and 5‐HT₂ Agonists in Rats

1989 • 61 citations

Functional Interaction between Serotonin and Other Neuronal Systems: Focus on In Vivo Microdialysis Studies

1996 • 60 citations

The anti-aversive action of minor tranquillizers

1984 • 60 citations

The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam

1989 • 59 citations

The effects of compounds acting at the benzodiazepine receptor complex on the ultrasonic calling of mouse pups.

1991 • 59 citations

Resident's scent: A critical factor in acute analgesic reaction to defeat experience in male mice

1986 • 59 citations

Alcohol, anxiolytics and social stress in rats

1995 • 58 citations

Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice

1990 • 56 citations

Effects of agents which interact with central benzodiazepine binding sites on stress-induced ultrasounds in rat pups

1987 • 56 citations

Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs

1996 • 56 citations

The differential activities of R(+)- and S(−)-zacopride as 5-HT3 receptor antagonists

1990 • 55 citations

Serotonin 5-HT3 antagonists do not alter the discriminative stimulus properties of cocaine

1991 • 55 citations

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

1989 • 54 citations

5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats

1990 • 53 citations

Cadaverine and putrescine initiate the burial of dead conspecifics by rats

1981 • 51 citations

Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats

1990 • 51 citations

Current and future trends in anticonvulsant, anxiety and stroke therapy

1989 • 49 citations

Modulation of the brain aversive system by GABAergic and serotonergic mechanisms

1986 • 47 citations

Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety

1992 • 45 citations

Preclinical anxiolytic versus antipsychotic profiles of the 5‐HT₃ antagonists ondansetron, zacopride, 3α‐tropanyl‐1H‐indole‐3‐carboxylic acid ester, and 1αH, 3α, 5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate

1991 • 44 citations

Rat pup ultrasonic vocalization: effects of benzodiazepine receptor ligands

1998 • 44 citations

Learned anticipatory rise in body temperature due to handling

1986 • 44 citations

The pharmacology of VA21B7: an atypical 5-HT3 receptor antagonist with anxiolytic-like properties in animal models

1995 • 43 citations

Serotonin Receptors And Their Ligands

1997 • 43 citations

Automatic quantification of withdrawal from 5-day diazepam in rats: ultrasonic distress vocalizations and hyperreflexia to acoustic startle stimuli

1993 • 42 citations

Antagonists at the serotonin-3 receptor can reduce the fear-potentiated startle response in the rat: evidence for different types of anxiolytic activity?

1994 • 41 citations

Effects of 5-HT4 receptor antagonists on rat behaviour in the elevated plus-maze test

1996 • 41 citations

5-HT(1A) receptors play an important role in modulation of behavior of rats in a two-compartment black and white box.

1996 • 40 citations

Behavioural Effects in Mice of Subchronic Chlordiazepoxide, Maprotiline and Fluvoxamine. II. The Elevated Plus-Maze

1997 • 40 citations

The ontogeny of defensive reactions in the rat: Influence of the monoamine transmission systems

1982 • 38 citations

A Controlled Trial of Ondansetron, a 5-HT3 Antagonist, in Benzodiazepine Discontinuation

1998 • 38 citations

Are the analgesic effects of social defeat mediated by benzodiazepine receptors?

1987 • 37 citations

The Effect of DAU 6215, A Novel 5HT-3 Antagonist, in Animal Models of Anxiety

1993 • 36 citations

Antagonism of [3H]zacopride binding to 5-HT3 recognition sites by its (R) and (S) enantiomers

1990 • 36 citations

Stimulus control of defensive burying in the rat

1980 • 36 citations

Cocaine discrimination is attenuated by isradipine and CGS 10746B

1993 • 34 citations

Effects of the 5-HT3 Antagonist, Ondansetron, on the Behavioral and Physiological Effects of Pentagastrin in Patients with Panic Disorder and Social Phobia

1997 • 33 citations

8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition

1990 • 32 citations

The effects of 5-HT 1A receptor agonists, 5-HT 1A receptor antagonists and their interaction on the fear-potentiated startle response

1998 • 30 citations

Highly potent inhibitory effects of 5-HT3 receptor antagonist, GR38032F, on non-opioid defeat analgesia in male mice

1990 • 30 citations

Serotonin: Actions, Receptors, Pathophysiology

1989 • 30 citations

Behavioural Effects in Mice of Subchronic Buspirone, Ondansetron and Tianeptine. II. The Elevated Plus-Maze

1997 • 30 citations

Fear-potentiated startle response is remarkably similar in two laboratories

1996 • 29 citations

GABA-B receptor activation and conflict behaviour

1988 • 29 citations

Inhibition by 5-HT3 receptor antagonists of release of cholecystokinin-like immunoreactivity from the frontal cortex of freely moving rats

1993 • 29 citations

Behavioural and neuropharmacological aspects of maternal aggression in rodents

1990 • 29 citations

Effects of 8-OH-DPAT, buspirone and ICS 205-930 on feeding in a novel environment: comparisons with chlordiazepoxide and FG 7142

1990 • 29 citations

An ethological study of the effects of buspirone and the 5-HT3 receptor antagonist, BRL 43694 (granisetron) on behaviour during social interactions in female and male mice

1991 • 28 citations

The effect of 5-HT3 receptor antagonists on the discriminative stimulus effects of amphetamine

1992 • 28 citations

Anxiolytic-like activity of R(+)- and S(−)-zacopride in mice

1991 • 27 citations

Ondansetron in the treatment of panic disorder

1996 • 26 citations

Behavioural effects in gerbils of the 5-HT3 receptor antagonists, BRL 43694 and ICS 205-930, under circumstances of high and low light intensity

1990 • 25 citations

Toward a neuroethology of mammalian vision

1981 • 25 citations

Studies on the role of 5-HT3 receptors in the mediation of the ethanol interoceptive cue

1996 • 25 citations

Behavioural Effects in Mice of Subchronic Chlordiazepoxide, Maprotiline, and Fluvoxamine. I. Social Interactions

1997 • 24 citations

Anxiolytic profile of GR 38032F in the potentiated startle paradigm

1989 • 24 citations

Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats

1993 • 24 citations

Profile of action of 5-HT3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice

1995 • 24 citations

Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands

1988 • 23 citations

Chronic administration of the 5-HT3 receptor antagonist BRL 43694; effects on reflex epilepsy and social behaviour of the Mongolian gerbil

1990 • 23 citations

Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flow

1991 • 23 citations

5-HT1A receptor full and partial agonists and 5-HT2C (but not 5-HT3) receptor antagonists increase rates of punished responding in rats

1995 • 21 citations

The anxiolytic-like effects of 5-hydroxytryptamine3 (5-HT3) receptor antagonists.

1992 • 21 citations

Discriminative stimulus properties of the serotonergic compound eltoprazine.

1992 • 20 citations

Detailed investigations of 5-HT3 compounds in a drug discrimination model

1996 • 20 citations

5-HT3 agonist 2-methylserotonin as a training drug in drug discrimination studies

1992 • 19 citations

A New Animal Model for Anticipatory Anxiety?

1991 • 19 citations

Behavioural and Hormonal Indices of Anxiolytic and Anxiogenic Drug Action in the Shock Prod Defensive Burying/Avoidance Paradigm

1991 • 19 citations

Section Review—Central & Peripheral Nervous Systems: 5-HT₃Receptor Antagonists in Development As-Anxiolytics

1995 • 16 citations

A study to evaluate the effect of ondansetron on psychomotor performance after repeated oral dosing in healthy subjects

1991 • 16 citations

Defensive burying in the Mongolian gerbil (Meriones unguiculatus) as a function of size and shape of the test chamber

1982 • 16 citations

Effects of granisetron and lorazepam, alone and in combination, on psychometric performance.

1991 • 16 citations

Further characterization of the discriminative stimulus effects of buspirone using monoamine agonists and antagonists in the pigeon

1989 • 16 citations

A mechanism of 5-HT3 receptor mediation is involved etiologically in the psychological stress lesion the stomach of the mouse.

1994 • 15 citations

A step in the right direction: comment on '5-HT and mechanisms of defence'

1991 • 15 citations

Pinch-induced catalepsy in mice: A useful model to investigate antidepressant or anxiolytic drugs

1998 • 13 citations

Drug Discrimination and Animal Models

1991 • 12 citations

Cross-species responses in the defensive burying paradigm: A comparison between Long-Evans rats (Rattus norvegicus), Richardson's ground squirrels (Spermophilus richardsonii), and thirteen-lined ground squirrels (Catellus tridecemlineatus).

1989 • 12 citations

Facilitating role of m-chlorophenylbiguanide in a cocaine discrimination

1995 • 11 citations

Further Characterization of the Discriminative Stimulus Induced by Flesinoxan

1991 • 10 citations

Classification of opioid and 5-hydroxytryptamine receptors by means of discriminative drug effects

1987 • 10 citations

An Anxiolytic-Like Effect of Ondansetron Disappears in Oxazepam-Tolerant Rats

1998 • 9 citations

Pharmacological Models in the Development of Antipsychotic Drugs — New Strategies

1991 • 9 citations

Cross-species responses in the defensive burying paradigm: A comparison between Long-Evans rats (Rattus norvegicus), Richardson's ground squirrels (Spermophilus richardsonii), and thirteen-lined ground squirrels (Catellus tridecemlineatus).

1989 • 9 citations

Defensive burying of aversive fluids in rats: The possible role of odor

1984 • 8 citations

WAY‐SEC‐579: A Novel 5‐HT₃ Receptor Antagonist

1996 • 7 citations

Zacopride and its optical isomers produce stereoselective antagonism of a 2-methylserotonin discriminative stimulus

1992 • 7 citations

Behavioural Correlates of the Activation of 5-HT Receptors

1989 • 6 citations

Novel anxiolytic agents: actions on specific subtypes of central 5-HT receptors.

1990 • 5 citations

Prior Repeated Exposure to a 5-HT3 Receptor Agonist Does Not Alter the Ethanol-Induced Conditioned Taste Aversion in Rats

1998 • 4 citations

Section Review: Central & Peripheral Nervous Systems: 5-HT3receptor antagonists as antiemetic agents in cancer chemotherapy

1996 • 4 citations

Extinction of Conflict Behaviour

1991 • 2 citations

Deleted Work

1955 • 0 citations