The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

2004 • 2,231 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

2008 • 1,347 citations

A circadian clock in macrophages controls inflammatory immune responses

2009 • 717 citations

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

2007 • 525 citations

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

2010 • 482 citations

Intrinsic Circadian Clock of the Mammalian Retina: Importance for Retinal Processing of Visual Information

2007 • 423 citations

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

2009 • 418 citations

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

2009 • 399 citations

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism

2001 • 374 citations

Susceptibility Rhythm to E. coli Endotoxin and Bioassay.

1960 • 263 citations

The Orphan Nuclear Receptor Rev-erbα Recruits the N-CoR/Histone Deacetylase 3 Corepressor to Regulate the Circadian Bmal1 Gene

2005 • 254 citations

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

2011 • 234 citations

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

2009 • 233 citations

Circadian dysfunction in disease

2010 • 199 citations

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

2011 • 191 citations

Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

2008 • 188 citations

Characterization of the Molecular Clock in Mouse Peritoneal Macrophages

2007 • 185 citations

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

2011 • 159 citations

Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis.

1992 • 133 citations

Overnight variations in cortisol, interleukin 6, tumour necrosis factor α and other cytokines in people with rheumatoid arthritis

2008 • 127 citations

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

2008 • 123 citations

Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands

2010 • 117 citations

DIURNAL VARIATION IN ENDOTOXIN-INDUCED MORTALITY IN MICE: CORRELATION WITH PROINFLAMMATORY FACTORS

2009 • 110 citations

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

2011 • 105 citations

NFIL3/E4BP4 controls type 2 T helper cell cytokine expression

2011 • 86 citations

Nuclear Receptors Homo sapiens Rev-erbβ and Drosophila melanogaster E75 Are Thiolate-Ligated Heme Proteins Which Undergo Redox-Mediated Ligand Switching and Bind CO and NO

2009 • 77 citations

The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

2009 • 67 citations

The Nuclear Receptor Rev-erbα Is a Liver X Receptor (LXR) Target Gene Driving a Negative Feedback Loop on Select LXR-Induced Pathways in Human Macrophages

2008 • 58 citations

Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription

2009 • 57 citations

Location, location, location: important for jet-lagged circadian loops

2010 • 36 citations

A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility

2009 • 22 citations

Deleted Work

1955 • 0 citations