The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

A new mathematical model for relative quantification in real-time RT-PCR

2001 • 32,396 citations

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

2008 • 2,939 citations

Astrocytes, from brain glue to communication elements: the revolution continues

2005 • 1,689 citations

Astroglia induce neurogenesis from adult neural stem cells

2002 • 1,422 citations

Astrocytes are active players in cerebral innate immunity

2007 • 1,225 citations

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

1993 • 1,009 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

2003 • 823 citations

Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury

2005 • 542 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

1997 • 482 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat

1998 • 417 citations

Staggerer, a New Mutation in the Mouse Affecting the Cerebellum

1962 • 369 citations

Interleukin-6 expression and regulation in astrocytes

1999 • 357 citations

The orphan nuclear receptor RORα is a negative regulator of the inflammatory response

2001 • 265 citations

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.

1995 • 191 citations

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

1999 • 189 citations

Sensory Impairments and Delayed Regeneration of Sensory Axons in Interleukin-6-Deficient Mice

1999 • 187 citations

Staggerer chimeras: Intrinsic nature of purkinje cell defects and implications for normal cerebellar development

1979 • 162 citations

Cell culture models for reactive gliosis: New perspectives

1998 • 136 citations

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism.

1999 • 112 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.

1994 • 109 citations

Stimulation of Interleukin‐6 Secretion and Gene Transcription in Primary Astrocytes by Adenosine

1997 • 101 citations

Immunohistochemical Characterization of the Orphan Nuclear Receptor RORα in the Mouse Nervous System

2004 • 88 citations

RORα in genetic control of cerebellum development: 50 staggering years

2006 • 86 citations

Rev-erbβ Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells

2004 • 85 citations

Retinoid-Related Orphan Receptor α Controls the Early Steps of Purkinje Cell Dendritic Differentiation

2006 • 84 citations

Evidence for a Hyperexcitability State of Staggerer Mutant Mice Macrophages

1992 • 79 citations

ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion.

1999 • 75 citations

The Structural Integrity of RORα Isoforms Is Mutated instaggererMice: Cerebellar Coexpression of RORα1 and RORα4

1997 • 75 citations

Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide

2003 • 74 citations

Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype

2007 • 70 citations

Enhanced susceptibility ofstaggerer(RORα^sg/sg) mice to lipopolysaccharide-induced lung inflammation

2005 • 69 citations

ICAM-1-Coupled Signaling Pathways in Astrocytes Converge to Cyclic AMP Response Element-Binding Protein Phosphorylation and TNF-α Secretion

1999 • 61 citations

Expression and regulation of the nuclear receptor RORα in human vascular cells

2001 • 52 citations

Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells

2002 • 48 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator

1994 • 39 citations

Modulation of the Far-Upstream Enhancer of the Rat α-Fetoprotein Gene by Members of the RORα, Rev-erbα, and Rev-erbβ Groups of Monomeric Orphan Nuclear Receptors

2000 • 37 citations

RORα1 and RORα4 suppress TNF‐α‐induced VCAM‐1 and ICAM‐1 expression in human endothelial cells

2003 • 34 citations

Abnormal IL-1β cytokine expression in the cerebellum of the ataxic mutant mice staggerer and Lurcher

1998 • 33 citations

The Gene Encoding Fibrinogen-β Is a Target for Retinoic Acid Receptor-Related Orphan Receptor α

2005 • 17 citations

Over-expression of interleukin-1β-converting enzyme mRNA in staggerer cerebellum

1996 • 10 citations

QUANTITATIVE ANALYSIS OF MICROGLIAL CELLS IN THE DEGENERATING CEREBELLUM OF THE STAGGERER (RORA^sg/sg) MUTANT MOUSE

2005 • 8 citations