The Virulence Activator AphA Links Quorum Sensing to Pathogenesis and Physiology in Vibrio cholerae by Repressing the Expression of a Penicillin Amidase Gene on the Small Chromosome

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Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

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Quorum Sensing in Bacteria

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Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR

1988 • 2,150 citations

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1995 • 1,189 citations

Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector

1986 • 1,053 citations

Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin.

1987 • 1,041 citations

Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

2002 • 826 citations

Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae

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Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein

1987 • 626 citations

A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains

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Positive selection vectors for allelic exchange

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Regulatory cascade controls virulence in Vibrio cholerae.

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A bacteriophage encoding a pathogenicity island, a type-IV pilus and a phage receptor in cholera bacteria

1999 • 386 citations

TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae

1998 • 318 citations

Culture Conditions for Stimulating Cholera Toxin Production byVibrio choleraeO1 El Tor

1986 • 270 citations

Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter

2002 • 226 citations

Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter

1989 • 223 citations

The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane‐localized transcriptional activators on a single promoter

2000 • 192 citations

A Vibrio cholerae LysR Homolog, AphB, Cooperates with AphA at the tcpPH Promoter To Activate Expression of the ToxR Virulence Cascade

1999 • 188 citations

Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae

1997 • 177 citations

A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains

1997 • 162 citations

Vibrio cholerae H-NS Silences Virulence Gene Expression at Multiple Steps in the ToxR Regulatory Cascade

2000 • 161 citations

A new level in the Vibrio cholerae ToxR virulence cascade: AphA is required for transcriptional activation of the tcpPH operon

1999 • 160 citations

Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP‐CRP at the Vibrio cholerae tcpPH promoter

2001 • 156 citations

Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation

2002 • 155 citations

PENICILLIN ACYLASE: ENZYME PRODUCTION AND ITS APPLICATION IN THE MANUFACTURE OF 6-APA

1989 • 153 citations

Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae

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Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens

1995 • 130 citations

Analysis of ToxR‐dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae

1998 • 127 citations

Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay

1992 • 124 citations

Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members.

1999 • 111 citations

The role of penicillin amidases in nature and in industry

1991 • 109 citations

Molecular cloning and transcriptional regulation of ompT, a ToxR‐repressed gene in Vibrio cholerae

2000 • 105 citations

Inducible Metabolism of Phenolic Acids inPediococcus pentosaceusIs Encoded by an Autoregulated Operon Which Involves a New Class of Negative Transcriptional Regulator

2000 • 102 citations

pepA , a Gene Mediating pH Regulation of Virulence Genes in Vibrio cholerae

2001 • 69 citations

Carbon regulation and the role in nature of the Escherichia coli penicillin acylase (pac) gene

1992 • 58 citations

Mechanism of ToxT-Dependent Transcriptional Activation at the Vibrio cholerae tcpA Promoter

2002 • 57 citations

Differential Activation of the tcpPH Promoter by AphB Determines Biotype Specificity of Virulence Gene Expression in Vibrio cholerae

2000 • 49 citations

ToxR interferes with CRP‐dependent transcriptional activation of ompT in Vibrio cholerae

2002 • 47 citations

Molecular cloning of Bacillus sphaericus penicillin V amidase gene and its expression in Escherichia coli and Bacillus subtilis

1985 • 37 citations

Binding site requirements of the virulence gene regulator AphB: differential affinities for the Vibrio cholerae classical and El Tor tcpPH promoters

2002 • 37 citations

Sequencing and heterologous expression of the gene encoding penicillin V amidase from Bacillus sphaericus

1986 • 30 citations

A new colorimetric method for the determination of 6-aminopenicillanic acid

1978 • 16 citations