Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP‐CRP at the Vibrio cholerae tcpPH promoter

Experiments in molecular genetics

1972 • 28,260 citations

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR

1988 • 2,150 citations

Improved single and multicopy lac-based cloning vectors for protein and operon fusions

1987 • 1,537 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Cholera

1995 • 1,189 citations

Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin.

1987 • 1,041 citations

MOLECULAR BIOLOGY OF THE LysR FAMILY OF TRANSCRIPTIONAL REGULATORS

1993 • 1,040 citations

Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans.

1988 • 703 citations

Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein

1987 • 626 citations

A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains

1998 • 493 citations

Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein

2003 • 461 citations

Positive selection vectors for allelic exchange

1996 • 459 citations

Regulatory cascade controls virulence in Vibrio cholerae.

1991 • 451 citations

Small broad-host-range gentamycin resistance gene cassettes for site-specific insertion and deletion mutagenesis.

1993 • 406 citations

A bacteriophage encoding a pathogenicity island, a type-IV pilus and a phage receptor in cholera bacteria

1999 • 386 citations

Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.

1984 • 320 citations

TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae

1998 • 318 citations

Regulation and Temporal Expression Patterns of Vibrio cholerae Virulence Genes during Infection

1999 • 291 citations

Culture Conditions for Stimulating Cholera Toxin Production byVibrio choleraeO1 El Tor

1986 • 270 citations

Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli

1997 • 242 citations

Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli

1984 • 241 citations

Conserved motifs in a divergent nod box of Azorhizobium caulinodans ORS571 reveal a common structure in promoters regulated by LysR-type proteins.

1992 • 235 citations

Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter

1989 • 223 citations

Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation

1991 • 217 citations

The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane‐localized transcriptional activators on a single promoter

2000 • 192 citations

A Vibrio cholerae LysR Homolog, AphB, Cooperates with AphA at the tcpPH Promoter To Activate Expression of the ToxR Virulence Cascade

1999 • 188 citations

The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators

1992 • 188 citations

The role of integration host factor In gene expression in Escherichia coli

1992 • 183 citations

Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae

1997 • 177 citations

A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains

1997 • 162 citations

Vibrio cholerae H-NS Silences Virulence Gene Expression at Multiple Steps in the ToxR Regulatory Cascade

2000 • 161 citations

A new level in the Vibrio cholerae ToxR virulence cascade: AphA is required for transcriptional activation of the tcpPH operon

1999 • 160 citations

Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae

1994 • 139 citations

Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae

1997 • 136 citations

Analysis of ToxR‐dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae

1998 • 127 citations

Single amino acid substitutions in the N‐terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance

1995 • 110 citations

Molecular cloning and transcriptional regulation of ompT, a ToxR‐repressed gene in Vibrio cholerae

2000 • 105 citations

Analysis of an Autoregulatory Loop Controlling ToxT, Cholera Toxin, and Toxin-Coregulated Pilus Production in Vibrio cholerae

1999 • 97 citations

Organization of tcp, acf, and toxT genes within a ToxT‐dependent operon

1995 • 95 citations

A Region of the Transmembrane Regulatory Protein ToxR That Tethers the Transcriptional Activation Domain to the Cytoplasmic Membrane Displays Wide Divergence among Vibrio Species

2000 • 92 citations

Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator

2000 • 90 citations

The Salmonella typhimurium virulence plasmid encodes a positive regulator of a plasmid-encoded virulence gene

1991 • 86 citations

[41] Regulation of cholera toxin by temperature, pH, and osmolarity

1994 • 83 citations

Transcriptional co‐activation at the ansB promoters: involvement of the activating regions of CRP and FNR when bound in tandem

1995 • 77 citations

Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus

1991 • 73 citations

pepA , a Gene Mediating pH Regulation of Virulence Genes in Vibrio cholerae

2001 • 69 citations

The roles of indoleglycerol phosphate and the Trpl protein in the expression oftrpBA fromPseudomonas aeruginosa

1990 • 65 citations

Molecular mechanism of negative autoregulation ofEscherichia coli crpgene

1991 • 63 citations

Differential Activation of the tcpPH Promoter by AphB Determines Biotype Specificity of Virulence Gene Expression in Vibrio cholerae

2000 • 49 citations

In vitro binding of the Salmonella dublin virulence plasmid regulatory protein SpvR to the promoter regions of spvA and spvR

1996 • 45 citations

Dual Transcriptional Regulation of the Escherichia coli Phosphate-Starvation-Inducible psiE Gene of the Phosphate Regulon by PhoB and the Cyclic AMP (cAMP)-cAMP Receptor Protein Complex

2000 • 44 citations

The metR binding site in the Salmonella typhimurium metH gene: DNA sequence constraints on activation

1991 • 41 citations

General Transduction in Vibrio cholerae

1981 • 40 citations

Cyclic AMP receptor protein functions as a repressor of the osmotically inducible promoter proP P1 in Escherichia coli

1997 • 39 citations

In vivo analysis of the interactions of the LysR‐like regulator SpvR with the operator sequences of the spvA and spvR virulence genes of Salmonella typhimurium

1998 • 38 citations

In vitro determination of the effect of indoleglycerol phosphate on the interaction of purified TrpI protein with its DNA-binding sites

1991 • 35 citations

Classical and El Tor Biotypes of Vibrio cholerae Differ in Timing of Transcription of tcpPH during Growth in Inducing Conditions

2000 • 25 citations

Nucleic Acids and Molecular Biology

1993 • 25 citations

Sequence and functional analysis of the gene encoding Vibrio cholerae cAMP receptor protein

1997 • 17 citations

Synergistic Activation of Transcription in E. coli

1997 • 12 citations