Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas.

World Health Organization Classification of Tumours

2002 • 5,829 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx

1970 • 1,261 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

Epstein-Barr virus: exploiting the immune system

2001 • 907 citations

Expression of Epstein–Barr Virus Transformation–Associated Genes in Tissues of Patients with EBV Lymphoproliferative Disease

1989 • 803 citations

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

1998 • 664 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

EPSTEIN-BARR VIRUS-INDUCED POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS

1999 • 529 citations

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

2000 • 452 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

1991 • 317 citations

Epstein-Barr virus strategy in normal and neoplastic B cells

1994 • 251 citations

Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.

1993 • 241 citations

Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy1

2002 • 237 citations

RAPAMYCIN: CLINICAL RESULTS AND FUTURE OPPORTUNITIES1

2001 • 224 citations

The immunosuppressive macrolide RAD inhibits growth of human Epstein–Barr virus-transformed B lymphocytes in vitro and in vivo : A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

2000 • 215 citations

Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells

1990 • 211 citations

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

1998 • 206 citations

Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma [see comments]

1995 • 156 citations

Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors

2001 • 156 citations

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

1997 • 146 citations

Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines.

1997 • 140 citations

The EBV Transforming Protein, Latent Membrane Protein 1, Mimics and Cooperates with CD40 Signaling in B Lymphocytes

1999 • 89 citations

SIROLIMUS FOR RESCUE AND PRIMARY IMMUNOSUPPRESSION IN TRANSPLANTED CHILDREN RECEIVING TACROLIMUS1,2

2001 • 88 citations

Epstein-Barr virus-immortalized B cells produce IL-6 as an autocrine growth factor.

1990 • 87 citations

Autocrine and paracrine regulation of human T cell IL-10 production.

1997 • 51 citations

Role of IL-6 in promoting growth of human EBV-induced B-cell tumors in severe combined immunodeficient mice.

1994 • 46 citations

Sirolimus Interferes with the Innate Response to Bacterial Products in Human Whole Blood by Attenuation of IL‐10 Production

2001 • 44 citations

Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder1

2002 • 41 citations

EFFECT OF CYCLOSPORINE AND TACROLIMUS ON THE GROWTH OF EPSTEIN-BARR VIRUS-TRANSFORMED B-CELL LINES1,2

1998 • 39 citations

PRODUCTION OF IL-4 AND IL-10 DOES NOT LEAD TO IMMUNE QUIESCENCE IN VASCULARIZED HUMAN ORGAN GRAFTS1

1996 • 38 citations

Control of human B cell tumor growth in severe combined immunodeficiency mice by monoclonal anti-B cell antibodies.

1992 • 35 citations

Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6

2000 • 34 citations