Epstein-Barr virus-immortalized B cells produce IL-6 as an autocrine growth factor.

Autocrine growth factors and cancer

1985 • 1,462 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

IL-1 stimulates IL-6 production in endothelial cells.

1989 • 541 citations

Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.

1987 • 320 citations

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies

1988 • 308 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.

1988 • 254 citations

Immortalized B lymphocytes produce B-cell growth factor

1984 • 204 citations

The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells.

1987 • 203 citations

Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.

1987 • 174 citations

Interleukin 6 gene expression in normal and neoplastic B cells.

1989 • 153 citations

Epstein-Barr Virus Infection and Immunoregulation in Man

1985 • 140 citations

Interleukin‐1 regulation of hematopoietic growth factor production by human stromal fibroblasts

1988 • 136 citations

The acute phase nature of interleukin 6: studies in Kawasaki disease and other febrile illnesses.

1989 • 133 citations

Self-stimulating growth factor production by B-cell lines derived from Burkitt's lymphomas and other lines transformed in vitro by Epstein-Barr virus.

1983 • 106 citations

Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor.

1987 • 105 citations

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.

1989 • 97 citations

Basic virological aspects of Epstein-Barr virus infection.

1988 • 70 citations

Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells.

1988 • 62 citations

Stimulation of EBV-activated human B cells by monocytes and monocyte products. Role of IFN-beta 2/B cell stimulatory factor 2/IL-6.

1988 • 62 citations

Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma

1988 • 59 citations

Precursor B cells transformed by Epstein-Barr virus undergo sterile plasma-cell differentiation: J-chain expression without immunoglobulin.

1988 • 49 citations

Ig isotypes produced by EBV-transformed B cells as a function of age and tissue distribution.

1988 • 48 citations

Interleukin 1α acts as an autocrine growth factor for RPMI1788, an Epstein‐Barr virus‐transformed human B cell line

1988 • 22 citations