Sirolimus Interferes with the Innate Response to Bacterial Products in Human Whole Blood by Attenuation of IL‐10 Production

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1994 • 4,698 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1975 • 908 citations

SIROLIMUS (RAPAMYCIN)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION

1999 • 886 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

The Toll-receptor family and control of innate immunity

1999 • 666 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

CD14: Cell surface receptor and differentiation marker

1993 • 600 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

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Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes

1994 • 347 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

1998 • 325 citations

Stimulation of monokine production by lipoteichoic acids

1991 • 288 citations

Regulation of Monocyte IL-10 Synthesis by Endogenous IL-1 and TNF-α: Role of the p38 and p42/44 Mitogen-Activated Protein Kinases

1998 • 270 citations

Binding of Bacterial Peptidoglycan to CD14

1998 • 265 citations

Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes.

1996 • 229 citations

The role of cell cycle‐mediated events in Alzheimer's disease

1999 • 220 citations

A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor α gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment

1999 • 197 citations

Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans

1993 • 194 citations

Analysis of the autolysins of Bacillus subtilis 168 during vegetative growth and differentiation by using renaturing polyacrylamide gel electrophoresis

1992 • 173 citations

Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids

1992 • 168 citations

GRAM-POSITIVE SEPSIS

1999 • 166 citations

Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes

2000 • 153 citations

Structural analysis of Bacillus subtilis 168 endospore peptidoglycan and its role during differentiation

1996 • 153 citations

Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level.

1992 • 152 citations

Peptidoglycan and teichoic acid fromStaphylococcus epidermidisstimulate human monocytes to release tumour necrosis factor-α, interleukin-1β and interleukin-6

1993 • 131 citations

Rapamycin Inhibits the Generation of Graft-Versus-Host Disease- and Graft-Versus-Leukemia-Causing T Cells by Interfering with the Production of Th1 or Th1 Cytotoxic Cytokines

1998 • 109 citations

Cyclosporin a modulation of tumor necrosis factor gene expression and effects in vitro and in vivo.

1990 • 75 citations

Rapamycin (sirolimus, rapamune)

1995 • 69 citations

FACTORS CONTRIBUTING TO THE DEVELOPMENT OF CHRONIC REJECTION IN HETEROTOPIC RAT HEART TRANSPLANTATION1

1997 • 64 citations

Autocrine and paracrine regulation of human T cell IL-10 production.

1997 • 51 citations

Infectious diseases in the liver transplant recipient.

1998 • 49 citations

LACK OF IL-10 AND IL-13 PRODUCTION BY HUMAN POLYMORPHONUCLEAR NEUTROPHILS

1998 • 48 citations

Lipoteichoic Acid Acts as an Antagonist and an Agonist of Lipopolysaccharide on Human Gingival Fibroblasts and Monocytes in a CD14-Dependent Manner

1999 • 48 citations

Sepsis

1999 • 45 citations

Bacterial infections after liver transplantation

1989 • 43 citations

Cytokine Modulation in Experimental Endotoxemia: Characterization of an ex vivo Whole Blood Model

2000 • 38 citations

CYCLOSPORIN A INHIBITS THE IN VIVO PRODUCTION OF INTERLEUKIN-1β AND TUMOUR NECROSIS FACTOR α, BUT NOT INTERLEUKIN-6, BY A T-CELL-INDEPENDENT MECHANISM

1996 • 31 citations

Heparin coating reduces cell activation and mediator release in an in vitro venovenous bypass model for liver transplantation

1998 • 31 citations

Septic shock in critically ill patients: Aetiology, management and outcome

1993 • 26 citations

Involvement of adenylate cyclase and p70 S6 -kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1

1999 • 17 citations

Heparin coating reduces cell activation and mediator release in an in vitro venovenous bypass model for liver transplantation

1998 • 8 citations

Expression of CD14 corrects the slow response to lipopolysaccharide in the 1B8 mutant of the B cell lymphoma 70Z/3

1998 • 8 citations

MODULATION BY LIPOPOLYSACCHARIDE OF INFLAMMATORY CYTOKINE PRODUCTION BY TWO T CELL LINES

1997 • 6 citations