Epstein-Barr virus: exploiting the immune system

VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA

1964 • 2,643 citations

Germinal Centers

1994 • 1,680 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Notch Signaling

1995 • 1,282 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells

1985 • 1,257 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation

1995 • 1,207 citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

1998 • 1,145 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

EBV Persistence in Memory B Cells In Vivo

1998 • 794 citations

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

1998 • 759 citations

Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease

1991 • 718 citations

Cancer of the Head and Neck

1989 • 677 citations

Marker Band in One Chromosome 14 from Burkitt Lymphomas

1972 • 628 citations

Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals

1998 • 591 citations

X-LINKED RECESSIVE PROGRESSIVE COMBINED VARIABLE IMMUNODEFICIENCY (DUNCAN'S DISEASE)

1975 • 553 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state

1994 • 499 citations

Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts

1992 • 493 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1,which simulates an activated CD40 receptor

1998 • 480 citations

Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell line containing herpes‐like virus

1968 • 474 citations

The Expression Pattern of Epstein-Barr Virus Latent Genes In Vivo Is Dependent upon the Differentiation Stage of the Infected B Cell

2000 • 462 citations

Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma

1988 • 447 citations

Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling

2000 • 436 citations

Latent membrane protein 1of Epstein-Barr virus mimics a constitutively active receptor molecule

1997 • 433 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses

1999 • 430 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

1991 • 415 citations

The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB

1997 • 397 citations

Germinal center development

1997 • 370 citations

Different Epstein--Barr virus--B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line

1990 • 347 citations

Latent membrane protein 1of Epstein-Barr virus interacts with JAK3 and activates STAT proteins

1999 • 346 citations

Memory B-cell persistence is independent of persisting immunizing antigen

2000 • 345 citations

A re‐examination of the epstein‐barr virus carrier state in healthy seropositive individuals

1985 • 336 citations

Epstein-Barr Virus–Infected Resting Memory B Cells, Not Proliferating Lymphoblasts, Accumulate in the Peripheral Blood of Immunosuppressed Patients

1999 • 330 citations

Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade

1997 • 320 citations

Integral membrane protein 2 of Epstein—barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

1995 • 318 citations

Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell

1997 • 315 citations

Regional specialization in the mucosal immune system: primed cells do not always home along the same track

1999 • 287 citations

Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations

1998 • 276 citations

The Proto-Oncogene c- myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2

1999 • 268 citations

Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus

1995 • 262 citations

Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes

1992 • 258 citations

EBV-Infected B Cells in Infectious Mononucleosis

2000 • 228 citations

A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1

1995 • 220 citations

Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity

1992 • 211 citations

IMMUNOHISTOLOGY OF EPSTEIN-BARR VIRUS-ASSOCIATED ANTIGENS IN B CELL DISORDERS FROM IMMUNOCOMPROMISED INDIVIDUALS

1990 • 211 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

Epstein-Barr virus susceptibility of normal human B lymphocyte populations.

1984 • 193 citations

Early events in Epstein-Barr virus infection provide a model for B cell activation.

1985 • 193 citations

Seroepidemiology of the Virus

1979 • 193 citations

Is EBV Persistence In Vivo a Model for B Cell Homeostasis?

1996 • 185 citations

Relationship between the Epstein‐Barr virus and undifferentiated nasopharyngeal carcinoma: Correlated nucleic acid hybridization and histopathological examination

1977 • 173 citations

THE TRANSMISSION OF INFECTIOUS MONONUCLEOSIS

1955 • 170 citations

Samter's Immunologic Diseases

2001 • 169 citations

Tonsillar memory B cells, latently infected with Epstein–Barr virus, express the restricted pattern of latent genes previously found only in Epstein–Barr virus-associated tumors

2000 • 154 citations

c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.

1996 • 152 citations

Latent Membrane Protein 2A-Mediated Effects on the Phosphatidylinositol 3-Kinase/Akt Pathway

2000 • 150 citations

Immunohistochemical Detection of the Epstein-Barr Virus–Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis

1997 • 147 citations

The Epstein-Barr Virus

1979 • 142 citations

A model for persistent infection with Epstein-Barr virus: The stealth virus of human B cells

1999 • 137 citations

Diet and nasopharyngeal carcinoma: A case‐control study in Guangzhou, China

1989 • 137 citations

Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7.

1996 • 136 citations

EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1

1994 • 132 citations

Localization of the Major NF-κB-activating Site and the Sole TRAF3 Binding Site of LMP-1 Defines Two Distinct Signaling Motifs

1997 • 131 citations

Cells Expressing the Epstein-Barr Virus Growth Program Are Present in and Restricted to the Naive B-Cell Subset of Healthy Tonsils

2000 • 122 citations

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2

1999 • 121 citations

The (YXXL/I)2 signalling motif found in the cytoplasmic segments of the bovine leukaemia virus envelope protein and Epstein-Barr virus latent membrane protein 2A can elicit early and late lymphocyte activation events.

1993 • 119 citations

Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.

1996 • 118 citations

Human immunodeficiency virus-associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression.

1993 • 113 citations

EBV Persistence Involves Strict Selection of Latently Infected B Cells

2000 • 111 citations

Vaccine strategies against Epstein‐Barr virus‐associated diseases: lessons from studies on cytotoxic T‐cell‐mediated immune regulation

1999 • 110 citations

The Molecular and Cellular Origins of Hodgkin's Disease

2000 • 102 citations

Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes.

1997 • 97 citations

X-Linked Lymphoproliferative Syndrome Registry report

1980 • 95 citations

M.A. Epstein and B.G. Achong, The Epstein-Barr virus Berlin, Heidelberg, New York (Springer-Verlag ed.) (1979).

1982 • 92 citations

Burkitt's Lymphoma: A Human Cancer Model

1986 • 85 citations

Burkitt's Lymphoma: A Human Cancer Model

1986 • 83 citations

X-linked lymphoproliferative syndrome.

1989 • 81 citations

Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells

2001 • 71 citations

Notch1IC Partially Replaces EBNA2 Function in B Cells Immortalized by Epstein-Barr Virus

2001 • 64 citations

Frequent expansion of Epstein-Barr virus (EBV) infected cells in germinal centres of tonsils from an area with a high incidence of EBV-associated lymphoma

1999 • 54 citations

The Epstein-Barr virus: a group 1 carcinogen?

1999 • 32 citations

Expression of epstein-barr virus encoded nuclear antigen 1 in benign and malignant tissues harbouring EBV.

1996 • 26 citations

Cancer of the head and neck. Nasopharyngeal cancer. Epidemiology and etiology

1972 • 10 citations

Epidemiology and Etiology

1972 • 8 citations

Deleted Work

1955 • 0 citations