Intracellular Assembly and Degradation of Apolipoprotein B-100-containing Lipoproteins in Digitonin-permeabilized HEP G2 Cells

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

1989 • 414 citations

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1994 • 218 citations

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

1990 • 192 citations

Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells.

1986 • 190 citations

Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.

1988 • 186 citations

Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally

1990 • 151 citations

Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells.

1989 • 150 citations

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells.

1993 • 134 citations

Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells.

1992 • 131 citations

Biosynthesis of Apolipoprotein B48-containing Lipoproteins

1996 • 129 citations

Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment.

1995 • 129 citations

Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.

1992 • 128 citations

The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.

1990 • 123 citations

Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester.

1994 • 119 citations

Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.

1994 • 108 citations

A vesicular intermediate in the transport of hepatoma secretory proteins from the rough endoplasmic reticulum to the Golgi complex.

1987 • 108 citations

Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver.

1993 • 106 citations

Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.

1992 • 97 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.

1993 • 86 citations

Synthesis and secretion of apolipoprotein B from cultured liver cells

1995 • 82 citations

Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution.

1989 • 77 citations

Brefeldin A Reversibly Inhibits the Assembly of ApoB Containing Lipoproteins in McA-RH7777 Cells

1995 • 72 citations

Apoprotein B100, an Inefficiently Translocated Secretory Protein, Is Bound to the Cytosolic Chaperone, Heat Shock Protein 70

1995 • 71 citations

Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment

1995 • 66 citations

Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine.

1993 • 60 citations

Transit and sorting of apolipoprotein B within the endoplasmic reticulum and Golgi compartments of isolated hepatocytes from normal and orotic acid-fed rats.

1993 • 55 citations

Pulse‐chase studies of the synthesis of apolipoprotein B in a human hepatoma cell line, Hep G2

1985 • 54 citations

The assembly and secretion of apoB-100-containing lipoproteins

1993 • 51 citations

Hormonal regulation of lipoprotein assembly and secretion

1993 • 44 citations

Mode of growth hormone administration influences triacylglycerol synthesis and assembly of apolipoprotein B-containing lipoproteins in cultured rat hepatocytes

1996 • 36 citations

Inhibition of Secretion of Truncated Apolipoproteins B by Monomethylethanolamine Is Independent of the Length of the Apolipoprotein

1995 • 32 citations

Intracellular degradation of apolipoprotein B generates an N-terminal 70 kDa fragment in the endoplasmic reticulum

1995 • 24 citations

[17] Preparation of semiintact cells for study of vesicular trafficking in Vitro

1993 • 5 citations

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