TR4 Orphan Receptor Represses the Human Steroid 21-Hydroxylase Gene Expression through the Monomeric AGGTCA Motif

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Molecular Biology of Steroid Hormone Synthesis*

1988 • 1,387 citations

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency*

2000 • 1,208 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

2000 • 867 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Structure of human steroid 21-hydroxylase genes.

1986 • 568 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.

1986 • 559 citations

An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

1996 • 535 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

2000 • 303 citations

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

1993 • 243 citations

Ad4BP/SF‐1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function

1996 • 204 citations

Molecular Pathways of Steroid Receptor Action

1992 • 166 citations

Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.

1994 • 148 citations

Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: A unique signaling pathway in the steroid receptor superfamily

1999 • 95 citations

TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.

1994 • 82 citations

Molecular Biology of Steroid and Nuclear Hormone Receptors

1998 • 79 citations

cAMP-dependent transcription of the human CYP21B (P-450C21) gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element.

1990 • 69 citations

Regulation of Peroxisome Proliferator-activated Receptor α-Induced Transactivation by the Nuclear Orphan Receptor TAK1/TR4

1998 • 65 citations

Multiple regulatory elements determine adrenocortical expression of steroid 21-hydroxylase.

1990 • 64 citations

Negative Feedback Control of the Retinoid-Retinoic Acid/Retinoid X Receptor Pathway by the Human TR4 Orphan Receptor, a Member of the Steroid Receptor Superfamily

1998 • 60 citations

Induction of the Intronic Enhancer of the Human Ciliary Neurotrophic Factor Receptor (CNTFRä) Gene by the TR4 Orphan Receptor

1997 • 59 citations

Identification of Human TR2 Orphan Receptor Response Element in the Transcriptional Initiation Site of the Simian Virus 40 Major Late Promoter

1995 • 57 citations

Identification of Direct Repeat 4 as a Positive Regulatory Element for the Human TR4 Orphan Receptor

1997 • 56 citations

Nuclear Orphan Receptors Regulate Transcription of the Gene for the Human Luteinizing Hormone Receptor

2000 • 56 citations

Transcriptional Regulatory Elements of the Human Gene for Cytochrome P450c21 (Steroid 21-Hydroxylase) Lie within Intron 35 of the Linked C4B Gene

1999 • 53 citations

Differential Regulation of Direct Repeat 3 Vitamin D3and Direct Repeat 4 Thyroid Hormone Signaling Pathways by the Human TR4 Orphan Receptor

1999 • 51 citations

Suppression of Gene Expression on the Simian Virus 40 Major Late Promoter by Human TR4 Orphan Receptor

1995 • 49 citations

Characterization of a regulatory region of the steroid 21-hydroxylase gene.

1986 • 47 citations

The Orphan Receptor TAK1 Acts as a Repressor of RAR-, RXR- and T3R-Mediated Signaling Pathways

1995 • 45 citations

A Novel Nuclear Receptor Heterodimerization Pathway Mediated by Orphan Receptors TR2 and TR4

1998 • 42 citations

TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily

1994 • 40 citations

Suppression of the Human Erythropoietin Gene Expression by the TR2 Orphan Receptor, a Member of the Steroid Receptor Superfamily

1996 • 39 citations

Expression of the orphan receptor TR4 during brain development of the rat

2000 • 19 citations

Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor.

1999 • 13 citations

Identification of the Human Aldolase A Gene as the First Induced Target for the TR2 Orphan Receptor, a Member of the Steroid Hormone Receptor Superfamily

1997 • 12 citations

Monomeric Nuclear Receptors

1998 • 2 citations