Monomeric Nuclear Receptors

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation

1994 • 1,604 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*

1993 • 1,009 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism

1994 • 764 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

The retinoid receptors.

1994 • 665 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.

1992 • 635 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily.

1990 • 483 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.

1994 • 434 citations

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

1987 • 434 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I

1992 • 375 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

From embryogenesis to metamorphosis: The regulation and function of drosophila nuclear receptor superfamily members

1995 • 347 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.

1988 • 300 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

FTZ-F1, a Steroid Hormone Receptor-like Protein Implicated in the Activation of fushi tarazu

1991 • 292 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

The N-terminal DNA-binding ‘zinc finger’ of the oestrogen and glucocorticoid receptors determines target gene specificity.

1988 • 265 citations

Identification of a Rat c-erbAα-Related Protein Which Binds Deoxyribonucleic Acid but does not Bind Thyroid Hormone

1988 • 254 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

1993 • 243 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

Stoichiometric and steric principles governing repression by nuclear hormone receptors.

1997 • 236 citations

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.

1996 • 233 citations

A Nuclear Hormone Receptor Corepressor Mediates Transcriptional Silencing by Receptors with Distinct Repression Domains

1996 • 233 citations

Identification of a new brain-specific transcription factor, NURR1

1992 • 229 citations

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

1992 • 216 citations

ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

1994 • 211 citations

Orphan nuclear receptors--the first eight years.

1996 • 206 citations

The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat

1995 • 204 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose- predominant expression and induction early in adipocyte differentiation

1994 • 203 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.

1992 • 190 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

DHR3: a Drosophila steroid receptor homolog.

1992 • 165 citations

Ecdysteroid Regulation and DNA Binding Properties of Drosophila Nuclear Hormone Receptor Superfamily Members

1995 • 164 citations

Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.

1991 • 163 citations

Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type.

1995 • 158 citations

Mechanisms of transactivation by retinoic acid receptors

1993 • 156 citations

Adrenocortical Function and Regulation of the Steroid 21-Hydroxylase Gene in NGFI-B-Deficient Mice

1995 • 146 citations

Orphan receptors: in search of a unifying hypothesis for activation.

1992 • 138 citations

RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver.

1993 • 130 citations

A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.

1996 • 121 citations

Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor

1995 • 121 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.

1994 • 116 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers

1994 • 116 citations

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

1993 • 115 citations

A Human Early Response Gene Homologous to Murine nur77 and Rat NGFI-B, and Related to the Nuclear Receptor Superfamily

1990 • 110 citations

Nonbiased identification of DNA sequences that bind thyroid hormone receptor alpha 1 with high affinity.

1993 • 109 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.

1994 • 109 citations

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

1996 • 107 citations

Functional Interactions between Retinoic Acid Receptor-related Orphan Nuclear Receptor (RORα) and the Retinoic Acid Receptors in the Regulation of the γF-Crystallin Promoter

1995 • 97 citations

Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.

1992 • 95 citations

NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.

1994 • 95 citations

Transcriptional Activation and Repression by RORα, an Orphan Nuclear Receptor Required for Cerebellar Development

1997 • 95 citations

Constitutive expression of the orphan receptor, Rev-erbA alpha, inhibits muscle differentiation and abrogates the expression of the myoD gene family.

1995 • 93 citations

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

1995 • 92 citations

Thyroid hormone alters the DNA binding properties of chicken thyroid hormone receptors α and β

1992 • 87 citations

Isolation and characterization of human TR3 receptor: A member of steroid receptor superfamily

1989 • 84 citations

FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

1994 • 78 citations

Orphan nuclear receptors--the first eight years

1996 • 76 citations

Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation

1995 • 75 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

1994 • 72 citations

Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription.

1990 • 71 citations

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers

1992 • 68 citations

Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.

1995 • 63 citations

Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development.

1994 • 54 citations

Orphan receptors: in search of a unifying hypothesis for activation

1992 • 54 citations

Thyroid Hormone Receptor Variant α2

1996 • 51 citations

Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor.

1996 • 49 citations

Different dimerization activities of alpha and beta thyroid hormone receptor isoforms

1993 • 48 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors

1994 • 47 citations

Constitutive expression of the orphan receptor, Rev-erbA alpha, inhibits muscle differentiation and abrogates the expression of the myoD gene family

1995 • 44 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator

1994 • 39 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb

1994 • 39 citations

Expression of nuclear hormone receptors in the rat supraoptic nucleus.

1995 • 37 citations

DNA-independent and DNA-dependent Mechanisms Regulate the Differential Heterodimerization of the Isoforms of the Thyroid Hormone Receptor with Retinoid X Receptor

1996 • 35 citations

NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3

1994 • 33 citations

A cell-specific nuclear receptor regulates the steroid hydroxylases

1995 • 30 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain

1994 • 30 citations

The Retinoids Biology, Chemistry, and Medicine. 2nd Edition

1994 • 26 citations

Transcriptional Activation and Repression by ROR , an Orphan Nuclear Receptor Required for Cerebellar Development

1997 • 25 citations

Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors

1992 • 24 citations

Expression of nuclear hormone receptors in the rat supraoptic nucleus

1995 • 15 citations

Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B

1993 • 6 citations