Transforming Growth Factor-β Promotes Survival of Mammary Carcinoma Cells through Induction of Antiapoptotic Transcription Factor DEC1

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

2004 • 3,727 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Metastasis: a question of life or death

2006 • 1,779 citations

TGFβ: the molecular Jekyll and Hyde of cancer

2006 • 1,228 citations

TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1999 • 969 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

2005 • 678 citations

Dec1 and Dec2 are regulators of the mammalian molecular clock

2002 • 654 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene

2007 • 459 citations

TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

2001 • 350 citations

Positive and negative regulation of TGF-β signaling

2000 • 333 citations

The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β

2005 • 306 citations

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

2000 • 265 citations

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

2004 • 228 citations

Dual role for TGF-?1 in apoptosis

2005 • 215 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

2006 • 190 citations

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

2001 • 178 citations

Ki26894, a novel transforming growth factor‐β type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line

2006 • 176 citations

Defective T cell activation and autoimmune disorder in Stra13-deficient mice

2001 • 167 citations

CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness

2005 • 157 citations

Molecular Characterization of the Novel Basic Helix–Loop–Helix Protein DEC1 Expressed in Differentiated Human Embryo Chondrocytes

1997 • 153 citations

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor KinaseIn vivo

2006 • 149 citations

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

2003 • 139 citations

The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter

2006 • 116 citations

Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells

2005 • 111 citations

Regulation of STRA13 by the von Hippel-Lindau Tumor Suppressor Protein, Hypoxia, and the UBC9/Ubiquitin Proteasome Degradation Pathway

2001 • 110 citations

Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation

2002 • 109 citations

DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter

2003 • 108 citations

Functional analysis of the basic helix‐loop‐helix transcription factor DEC1 in circadian regulation

2004 • 107 citations

The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers

2004 • 100 citations

DEC1 (STRA13) protein expression relates to hypoxia‐ inducible factor 1‐alpha and carbonic anhydrase‐9 overexpression in non‐small cell lung cancer

2003 • 87 citations

DEC1 is a downstream target of TGF-β with sequence-specific transcriptional repressor activities

2002 • 86 citations

Identification of Genes Differentially Induced by Hypoxia in Pancreatic Cancer Cells

2001 • 81 citations

Autocrine TGFβ supports growth and survival of human breast cancer MDA-MB-231 cells

2002 • 77 citations

Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer

2006 • 68 citations

Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1 ) and the HIF-1 target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

2004 • 68 citations

Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski

2003 • 64 citations

The hypoxia‐regulated transcription factor DEC1 (Stra13, SHARP‐2) and its expression in human tissues and tumours

2004 • 58 citations

Effects of overexpression of basic helix–loop–helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells

2006 • 57 citations

SHARP‐2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression

2005 • 29 citations

DEC1 expression in 1p-aberrant oligodendroglial neoplasms.

2005 • 16 citations