The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Two major Smad pathways in TGF‐β superfamily signalling

2002 • 647 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 • 419 citations

Endogenous TGF-β signaling suppresses maturation of osteoblastic mesenchymal cells

2004 • 327 citations

Cooperative Inhibition of Bone Morphogenetic Protein Signaling by Smurf1 and Inhibitory Smads

2003 • 316 citations

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

2002 • 306 citations

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

2001 • 306 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Smad6 Is a Smad1/5-induced Smad Inhibitor

2000 • 277 citations

Targeting the TGFβ signaling network in human neoplasia

2003 • 245 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell–derived endothelial cells

2003 • 169 citations

Regulation of TGF‐β signaling and its roles in progression of tumors

2003 • 163 citations

A role for Id in the regulation of TGF-β-induced epithelial–mesenchymal transdifferentiation

2004 • 144 citations

A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells.

1999 • 116 citations

Chromosomal Region Maintenance 1 (CRM1)-dependent Nuclear Export of Smad Ubiquitin Regulatory Factor 1 (Smurf1) Is Essential for Negative Regulation of Transforming Growth Factor-β Signaling by Smad7

2003 • 94 citations

Clinical significance of the expression of activin A in esophageal carcinoma

2003 • 47 citations