Significant Antitumor Effects Obtained by Autologous Tumor Cell Vaccine Engineered to Secrete Interleukin (IL)-12 and IL-18 by Means of the EBV/Lipoplex

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.

2000 • 418 citations

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

1997 • 398 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Development and application of adenoviral vectors for gene therapy of cancer

1999 • 183 citations

Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study

1998 • 167 citations

Adjuvant active specific immunotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise

2001 • 133 citations

Potent antitumor effects mediated by local expression of the mature form of the interferon-γ inducing factor, interleukin-18 (IL-18)

1999 • 118 citations

Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer

2000 • 104 citations

Recombinant viruses as a tool for therapeutic vaccination against human cancers

2000 • 99 citations

In vivo electroporation-mediated transfer of interleukin-12 and interleukin-18 genes induces significant antitumor effects against melanoma in mice

2001 • 99 citations

Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

1998 • 98 citations

The influence of major histocompatibility complex class I antigens on tumor growth and metastasis

1987 • 80 citations

Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1β converting enzyme cDNA

1999 • 76 citations

Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer

2000 • 62 citations

Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines.

1998 • 58 citations

Synergistic antitumor effects of interleukin-12 gene transfer and systemic administration of interleukin-18 in a mouse bladder cancer model

1999 • 58 citations

Extremely efficient gene transfection into lympho-hematopoietic cell lines by Epstein-Barr virus-based vectors

1997 • 56 citations

Highly efficient gene transfer into murine liver achieved by intravenous administration of naked Epstein–Barr virus (EBV)-based plasmid vectors

2001 • 54 citations

Immunotherapy of Melanoma: A Dichotomy in the Requirement for IFN-γ in Vaccine-Induced Antitumor Immunity Versus Adoptive Immunotherapy

2001 • 51 citations

Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter

2000 • 50 citations

Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration

2000 • 48 citations

IL-12 Induces Monocyte IL-18 Binding Protein Expression Via IFN-γ

2002 • 47 citations

Gene Transferin vitroandin vivowith Epstein-Barr Virus-Based Episomal Vector Results in Markedly High Transient Expression in Rodent Cells

1998 • 43 citations

Interferons and cell growth control.

2000 • 39 citations

Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a phase 1 study

2001 • 38 citations

The ups and downs of adenovirus vectors.

1996 • 37 citations

Efficient Gene Transduction by Epstein–Barr-Virus-Based Vectors Coupled with Cationic Liposome and HVJ-Liposome

1997 • 37 citations

Successful transfer of ADA gene in vitro into human peripheral blood CD34⁺ cells by transfecting EBV‐based episomal vectors

1998 • 32 citations

Direct intra-cardiomuscular transfer of β2-adrenergic receptor gene augments cardiac output in cardiomyopathic hamsters

2000 • 32 citations

Interferons: Biological and clinical effects

1989 • 26 citations

Successful immunogene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature interleukin-18 cDNA and the Igκ leader sequence

2001 • 26 citations

Immunotherapy for Lung Metastases of Murine Renal Cell Carcinoma

1999 • 22 citations

GVAX (Cell Genesys).

2001 • 19 citations

Antitumor response to recombinant murine interferon ? correlates with enhanced immune function of organ-associated, but not recirculating cytolytic T lymphocytes and macrophages

1993 • 11 citations

In vivo gene transfer into rat hearts with Epstein-Barr virus-based episomal vectors using a gene gun

2000 • 7 citations

Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter

2002 • 4 citations