IL-12 Induces Monocyte IL-18 Binding Protein Expression Via IFN-γ

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Interleukin-18 Binding Protein

1999 • 759 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

2000 • 335 citations

A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

1997 • 325 citations

Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

1998 • 324 citations

Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response.

2000 • 274 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

Interleukin-18, a proinflammatory cytokine.

2000 • 236 citations

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

1998 • 151 citations

Induction of circulating IL-1 receptor antagonist by IFN treatment.

1993 • 137 citations

Interleukin-1β costimulates interferon-γ production by human natural killer cells

2001 • 115 citations

Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-gamma production, and expansion of natural killer cells.

2001 • 110 citations

Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells.

2000 • 80 citations

Interleukin‐12 Induces Sustained Activation of Multiple Host Inflammatory Mediator Systems in Chimpanzees

1999 • 74 citations

Antitumor Effects on Mouse Melanoma Elicited by Local Secretion of Interleukin-12 and Their Enhancement by Treatment with Interleukin-18

2000 • 54 citations

Interferon-??-Inducing Factor Elicits Antitumor Immunity Association with Interferon-?? Production

1998 • 35 citations

LIPOPOLYSACCHARIDE/ENDOTOXIN INDUCES IL-18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO

2000 • 32 citations