ESSENTIAL ROLE FOR G PROTEINS IN PROSTATE CANCER CELL GROWTH AND SIGNALING

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

G Protein-coupled Receptors

1998 • 1,033 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Activation of mitogen-activated protein kinase associated with prostate cancer progression.

1999 • 539 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

1998 • 440 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

1998 • 333 citations

Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma

1998 • 300 citations

Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

1997 • 276 citations

Bombesin stimulates growth of human prostatic cancer cellsin vitro

1990 • 227 citations

Differential Effects of Peptide Hormones Bombesin, Vasoactive Intestinal Polypeptide and Somatostatin Analog RC-160 on the Invasive Capacity of Human Prostatic Carcinoma Cells

1993 • 149 citations

Cell Type–Specific Angiotensin II–Evoked Signal Transduction Pathways

1998 • 141 citations

Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.

1997 • 134 citations

Review of Peptide Growth Factors in Benign Prostatic Hyperplasia and Urological Malignancy

1995 • 129 citations

Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes

1998 • 124 citations