Lysophosphatidic acid signalling

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Platelet-activating factor: a phospholipid autacoid with diverse actions

1993 • 253 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta

1994 • 195 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

1992 • 188 citations

Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.

1993 • 186 citations

Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

1994 • 186 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

1994 • 168 citations

Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator

1994 • 152 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

LPA: a novel lipid mediator with diverse biological actions

1994 • 139 citations

The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin

1994 • 137 citations

Lysophosphatidic acid alters cerebrovascular reactivity in piglets

1995 • 120 citations

Signalling properties of lysophosphatidic acid

1993 • 112 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid.

1994 • 105 citations

Effect of lysophospholipids on signaling in the human Jurkat T cell line

1995 • 88 citations

Biochemical Characterization of the Interaction of Lipid Phosphoric Acids with Human Platelets: Comparison with Platelet Activating Factor

1994 • 81 citations

Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade

1994 • 72 citations

Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

1993 • 70 citations

Identification and characterization of a lysophosphatidic acid receptor.

1994 • 64 citations

Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism

1994 • 61 citations

Effect of lysophosphatidic acid on the preimplantation development of mouse embryos

1994 • 58 citations

Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

1993 • 57 citations

Lysophosphatidic acid enhances fibronectin binding to adherent cells.

1993 • 41 citations

Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts

1992 • 40 citations

Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts

1994 • 40 citations

Purification of a lysophosphatidic acid-hydrolysing lysophospholipase from rat brain

1994 • 36 citations

Wortmannin Inhibits Serum-Induced Activation of Phosphoinositide 3-Kinase and Proliferation of CHRF-288 Cells

1994 • 33 citations

Identification and Characterization of an Ecto-(lyso)phosphatidic Acid Phosphatase in PAM212 Keratinocytes

1994 • 32 citations

A physiological role for PAF in the stimulation of mammalian embryonic development

1991 • 18 citations

A serum factor inducing neurite retraction of morphologically differentiated neuroblastoma × glioma NG108-15 cells

1989 • 6 citations