Generation of superoxide in cardiomyocytes during ischemia before reperfusion

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Nitric Oxide and Cardiac Function

1996 • 721 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

1994 • 637 citations

Molecular oxygen: Friend and foe*The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury

1984 • 543 citations

The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart

1982 • 523 citations

Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.

1993 • 518 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

1998 • 470 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Significant Levels of Oxidants are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

1997 • 391 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Significance of xanthine oxidase in capillary endothelial cells.

1986 • 333 citations

Calibration of Oxygen-Dependent Quenching of the Phosphorescence of Pd-meso-tetra (4-Carboxyphenyl) Porphine: A Phosphor with General Application for Measuring Oxygen Concentration in Biological Systems

1996 • 244 citations

Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectroscopy

1995 • 243 citations

The mitochondrial site of superoxide formation

1986 • 208 citations

Reperfusion injury on cardiac myocytes after simulated ischemia

1996 • 190 citations

Mechanism of Superoxide Generation by Neuronal Nitric-oxide Synthase

1999 • 186 citations

Mitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues

1991 • 174 citations

Mitochondrial Electron Transport can Become a Significant Source of Oxidative Injury in Cardiomyocytes

1997 • 161 citations

Lactate and P <scp>o</scp> ₂ Modulate Superoxide Anion Production in Bovine Cardiac Myocytes

1997 • 146 citations

In vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury.

1984 • 136 citations

Spin trapping of oxygen and carbon-centered free radicals in ischemic canine myocardium

1987 • 126 citations

Myocardial damage during ischaemia and reperfusion

1993 • 115 citations

A novel superoxide radical generator in heart mitochondria

1987 • 94 citations

Evidence for nitric oxide generation in the cardiomyocytes: its augmentation by hypoxia

1995 • 74 citations

Potential role of NADH oxidoreductase-derived reactive O2 species in calf pulmonary arterial PO2-elicited responses

1995 • 64 citations

Cellular, biochemical, and molecular aspects of reperfusion injury

1994 • 63 citations

Inhibition of DNA-ethidium bromide intercalation due to free radical attack upon DNA

1984 • 52 citations

Developmental changes and control of xanthine dehydrogenases in developing chicks

1967 • 44 citations

Preconditioning and Antioxidant Defense against Reperfusion Injury a

1994 • 34 citations

A potassium channel opener as monotherapy in chronic stable angina pectoris: comparison with placebo

1993 • 21 citations

Importance of free radicals generated by endothelial and myocardial cells in ischemia and reperfusion

1990 • 17 citations