Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon)

1974 • 1,255 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Amino-acid Sequence of Substance P

1971 • 769 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat

1976 • 758 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Central nervous system mechanisms of analgesia

1976 • 710 citations

Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.

1970 • 678 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

1977 • 617 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section

1975 • 443 citations

Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

1973 • 425 citations

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

1974 • 417 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat

1975 • 307 citations

Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

1977 • 303 citations

Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway.

1976 • 289 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).

1967 • 278 citations

Naloxone reversal of analgesia produced by brain stimulation in the human

1976 • 261 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Stimulation-produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

1975 • 250 citations

The effects of substance P and other peptides on spinal neurons of the frog

1974 • 207 citations

Substance P and analgesia

1976 • 202 citations

Neuroanatomical substrates of nociception in the spinal cord

1975 • 199 citations

Electro-acupuncture. Effect on pain threshold measured with electrical stimulation of teeth

1973 • 191 citations

CAUSALGIA TREATED BY SELECTIVE LARGE FIBRE STIMULATION OF PERIPHERAL NERVE

1972 • 118 citations

Suppression by LSD of the inhibitory effect exerted by dorsal raphe stimulation on certain spinal cord interneurons in the cat

1973 • 111 citations

Presence of Substance P‐Like Immunoreactivity in Plasma from Man and Dog

1975 • 106 citations

New long latency bulbospinal evoked potentials blocked by serotonin antagonists

1974 • 79 citations

Analgesia produced by brain stimulation: Evidence of a prolonged onset period

1974 • 72 citations

Pain threshold alterations by brain stimulation in the monkey

1971 • 71 citations

[Comparison in the rat between analgesia induced by stimulation of periacqueducal gray matter and morphine analgesia].

1972 • 46 citations