Definition of an Immunologic Response Using the Major Histocompatibility Complex Tetramer and Enzyme-Linked Immunospot Assays

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Biological Variation: From Principles to Practice

2001 • 625 citations

Antitumor Activity in Melanoma and Anti-Self Responses in a Phase I Trial With the Anti-Cytotoxic T Lymphocyte–Associated Antigen 4 Monoclonal Antibody CP-675,206

2005 • 584 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy

2002 • 303 citations

Current Developments in Cancer Vaccines and Cellular Immunotherapy

2003 • 300 citations

On the calculation of a "reference change" for comparing two consecutive measurements.

1983 • 262 citations

Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma.

2003 • 257 citations

Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor α in response to HLA-A2.1-binding melanoma and viral peptide antigens

1996 • 179 citations

Assays for monitoring cellular immune responses to active immunotherapy of cancer.

2001 • 167 citations

Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells.

1994 • 142 citations

Reverse ELISPOT assay for clonal analysis of cytokine production

1992 • 135 citations

Evaluation of the interferon-γ ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood

1997 • 133 citations

T Cell Responses to HLA-A*0201-Restricted Peptides Derived from Human α Fetoprotein

2001 • 128 citations

A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients.

1997 • 124 citations

The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays

2002 • 124 citations

Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT

2005 • 121 citations

Role of Dendritic Cell Phenotype, Determinant Spreading, and Negative Costimulatory Blockade in Dendritic Cell-Based Melanoma Immunotherapy

2004 • 119 citations

Evaluation of the Modified ELISPOT Assay for Gamma Interferon Production in Cancer Patients Receiving Antitumor Vaccines

2000 • 101 citations

The use of a rapid ELISPOT assay to analyze peptide-specific immune responses in carcinoma patients to peptide vs. recombinant poxvirus vaccines

2000 • 79 citations

Expansion of Tumor-T Cell Pairs from Fine Needle Aspirates of Melanoma Metastases

2000 • 76 citations

Enumerating Antigen-Specific T-Cell Responses in Peripheral Blood

2004 • 71 citations

Temporal Changes in the Concentrations of Serum Constituents in Healthy Men

1979 • 56 citations

Competition of peptide-MHC class I tetrameric complexes with anti-CD3 provides evidence for specificity of peptide binding to the TCR complex

2000 • 52 citations

Recombinant poxvirus vaccines

1993 • 42 citations

Ex Vivo Analysis of Human Antigen-Specific CD8+ T-Cell Responses: Quality Assessment of Fluorescent HLA-A2 Multimer and Interferon-γ ELISPOT Assays for Patient Immune Monitoring

2004 • 41 citations

On the calculation of reference change values, with examples from a long-term study

1993 • 36 citations

Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy

2000 • 32 citations

Reference Change Value for α-Fetoprotein and Its Application in Early Detection of Hepatocellular Carcinoma in Patients with Hepatic Disease

2003 • 29 citations

Improved permeabilization procedure for flow cytometric detection of internal antigens Analysis of interleukin-2 production

1991 • 28 citations

Enumeration of interleukin-1 alpha and beta producing cells by flow cytometry

1992 • 6 citations