Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function

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2003 • 1,251 citations

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

1997 • 843 citations

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1992 • 733 citations

Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mice

1998 • 704 citations

STUDIES IN VIVO ON THE RELATIONSHIP BETWEEN BRAIN TRYPTOPHAN, BRAIN 5‐HT SYNTHESIS AND HYPERACTIVITY IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR AND L‐TRYPTOPHAN

1971 • 667 citations

Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals

1993 • 502 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse.

1994 • 408 citations

Non‐linear pharmacokinetics of MDMA (‘ecstasy’) in humans

2000 • 397 citations

Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals

1985 • 371 citations

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3, 4-methylenedioxymethamphetamine

1992 • 357 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat

1998 • 345 citations

Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery

1999 • 340 citations

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

1994 • 336 citations

SPECT imaging of striatal dopamine release after amphetamine challenge.

1995 • 330 citations

Extracellular Concentrations of Cocaine and Dopamine Are Enhanced During Chronic Cocaine Administration

1990 • 321 citations

MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons

1988 • 318 citations

Effects of enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1986 • 312 citations

Cognitive performance in (±) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study

1999 • 305 citations

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1987 • 301 citations

Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

1988 • 299 citations

(±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates

1988 • 294 citations

Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users

1999 • 286 citations

Dopaminergic Mechanisms in Idiopathic and Drug-induced Psychoses

1990 • 279 citations

Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")

1995 • 268 citations

Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users

2000 • 267 citations

Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites

1983 • 258 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse.

1994 • 254 citations

Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons

2001 • 253 citations

The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA (`ecstasy')

1998 • 244 citations

The demethylenation of methylenedioxymethamphetamine (“ecstasy”) by debrisoquine hydroxylase (CYP2D6)

1994 • 237 citations

Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity

2004 • 232 citations

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat

1988 • 224 citations

The pharmacology of the acute hyperthermic response that follows administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats

2002 • 223 citations

The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine

1992 • 209 citations

Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs (‘Ecstasy’)

2000 • 204 citations

Acute and subchronic effects of methylenedioxymethamphetamine [(±)MDMA] on locomotion and serotonin syndrome behavior in the rat

1989 • 200 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats.

1990 • 194 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

THE EFFECTS OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA, “ECSTASY”) ON MONOAMINERGIC NEUROTRANSMISSION IN THE CENTRAL NERVOUS SYSTEM

1996 • 185 citations

An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine.

1998 • 183 citations

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.

1988 • 182 citations

3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose

2001 • 181 citations

RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy")

2002 • 179 citations

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by <scp>l</scp>‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor

1971 • 179 citations

In vivo evidence for free radical involvement in the degeneration of rat brain 5‐HT following administration of MDMA (‘ecstasy’) and p‐chloroamphetamine but not the degeneration following fenfluramine

1997 • 176 citations

Carrier‐dependent and Ca²⁺‐dependent 5‐HT and dopamine release induced by (+)‐amphetamine, 3,4‐methylendioxy‐methamphetamine, p‐chloroamphetamine and (+)‐fenfluramine

1997 • 175 citations

Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies

1998 • 174 citations

The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype

1995 • 168 citations

MDMA induced dopamine release in vivo: role of endogenous serotonin

1997 • 166 citations

3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.

1989 • 162 citations

Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine.

1996 • 162 citations

MDMA Elicits Behavioral and Neurochemical Sensitization in Rats

1998 • 159 citations

The pre-clinical behavioural pharmacology of 3,4-methylenedioxymethamphetamine (MDMA)

2003 • 158 citations

Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin

1993 • 157 citations

PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects

1997 • 151 citations

Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.

1995 • 151 citations

Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion

1996 • 149 citations

Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists

1994 • 148 citations

Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.

1995 • 148 citations

Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat.

1996 • 147 citations

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1989 • 146 citations

3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions.

2001 • 145 citations

Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity.

1998 • 145 citations

In vivo detection of short- and long-term MDMA neurotoxicity?a positron emission tomography study in the living baboon brain

1998 • 143 citations

Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate

1991 • 143 citations

Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors.

1999 • 138 citations

Acute psychological and physiological effects of MDMA (“Ecstasy”) after haloperidol pretreatment in healthy humans

2000 • 138 citations

5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

1993 • 137 citations

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1990 • 134 citations

Molecular genetics of the debrisoquin-sparteine polymorphism

1991 • 132 citations

Differences in the central serotonergic effects of Methylenedioxymethamphetamine (MDMA) in mice and rats

1987 • 131 citations

Hyperthermia following MDMA administration in rats: Effects of ambient temperature, water consumption, and chronic dosing

1995 • 130 citations

Neurotoxic Amphetamine Analogues: Effects in Monkeys and Implications for Humans^a

1992 • 127 citations

Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors.

1991 • 127 citations

Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity

1988 • 126 citations

A study of the mechanisms involved in the neurotoxic action of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) on dopamine neurones in mouse brain

2001 • 125 citations

A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration

1999 • 124 citations

Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user

2000 • 120 citations

In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector

1988 • 118 citations

Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice

2003 • 116 citations

The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

1995 • 113 citations

Glutathione and N-Acetylcysteine Conjugates of α-Methyldopamine Produce Serotonergic Neurotoxicity: Possible Role in Methylenedioxyamphetamine-Mediated Neurotoxicity

1999 • 111 citations

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) in rats

1994 • 111 citations

Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)

1988 • 110 citations

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.

1996 • 109 citations

3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes Motor Activity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primates

2003 • 106 citations

3,4-Dihydroxymethamphetamine (HHMA). A Major in Vivo 3,4-methylenedioxymethamphetamine (MDMA) Metabolite in Humans

2001 • 103 citations

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA (‘ecstasy’) on the 5-HT and dopamine concentrations in mouse brain

2001 • 103 citations

Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat

1999 • 102 citations

Pharmacological Studies of the Acute Effects of (+)-3,4-Methylenedioxymethamphetamine on Locomotor Activity, Role of 5-HT1B/1D and 5-HT2 Receptors

2002 • 101 citations

Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate.

1989 • 99 citations

2,5-bis-(Glutathion-S-yl)-α-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

1997 • 94 citations

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies.

1996 • 94 citations

CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA)

1994 • 93 citations

Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT 1B receptor

1999 • 91 citations

Acute administration of methylenedioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs

1987 • 91 citations

Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement

2002 • 89 citations

Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy)

1999 • 89 citations

Dopaminergic and serotonergic mechanisms of thermoregulation: mediation of thermal effects of apomorphine and dopamine.

1983 • 88 citations

A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA

1989 • 88 citations

Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood

2003 • 87 citations

5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates

1988 • 87 citations

Neurotoxicity of MDMA: Neurochemical Effects

1990 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

Studies on the role of dopamine in the degeneration of 5‐HT nerve endings in the brain of Dark Agouti rats following 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration

1999 • 84 citations

Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats

1994 • 83 citations

Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn‐superoxide dismutase transgenic mice

1995 • 83 citations

Reserpine attenuates d-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis

1998 • 83 citations

Studies, using in vivo microdialysis, on the effect of the dopamine uptake inhibitor GBR 12909 on 3,4-methylenedioxymethamphetamine (‘ecstasy’)-induced dopamine release and free radical formation in the mouse striatum

2002 • 80 citations

Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo

1994 • 80 citations

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

1991 • 78 citations

Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

1992 • 76 citations

The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: Evidence for the protective effect of chlormethiazole

1992 • 76 citations

Methylenedioxymethamphetamine Decreases Plasmalemmal and Vesicular Dopamine Transport: Mechanisms and Implications for Neurotoxicity

2002 • 74 citations

Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst

1999 • 72 citations

Effect of 3,4-Methylenedioxymethamphetamine (MDMA) on Hippocampal Dopamine and Serotonin

1998 • 72 citations

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature

2002 • 71 citations

Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]β-CIT SPECT study – preliminary report

2001 • 71 citations

Mazindol Attenuates the 3,4‐Methylenedioxymethamphetamine‐Induced Formation of Hydroxyl Radicals and Long‐Term Depletion of Serotonin in the Striatum

1999 • 68 citations

Effects of 7‐Nitroindazole, an NOS Inhibitor on Methamphetamine‐Induced Dopaminergic and Serotonergic Neurotoxicity in Mice^a

1998 • 67 citations

Enzymic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

1992 • 67 citations

nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice

2000 • 66 citations

Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse

2003 • 64 citations

Retraction

2003 • 64 citations

A study of the mechanism of MDMA (‘Ecstasy’)‐induced neurotoxicity of 5‐HT neurones using chlormethiazole, dizocilpine and other protective compounds

1994 • 63 citations

Effects of Intracerebroventricular Administration of 5-(Glutathion-S-yl)-α-methyldopamine on Brain Dopamine, Serotonin, and Norepinephrine Concentrations in Male Sprague-Dawley Rats

1996 • 63 citations

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1990 • 61 citations

Study of naloxone in normal awake man: Effects on heart rate and respiration

1979 • 59 citations

L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats

1991 • 59 citations

Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems.

1992 • 56 citations

Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl]propane [(methylenedioxy)methamphetamine]

1992 • 56 citations

Enhancement of 3,4‐methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate

2001 • 55 citations

Serotonergic Neurotoxicity of 3,4-(±)-Methylenedioxyamphetamine and 3,4-(±)-Methylendioxymethamphetamine (Ecstasy) Is Potentiated by Inhibition of γ-Glutamyl Transpeptidase

2001 • 55 citations

Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the wistar rat

2001 • 54 citations

Pre-Exposure to (±)3,4-methylenedioxy-methamphetamine (MDMA) Facilitates Acquisition of Intravenous Cocaine Self-Administration in Rats

2001 • 52 citations

Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice

1997 • 52 citations

Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats.

1994 • 51 citations

Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3,4-methylenedioxymethamphetamine (MDMA)

2000 • 50 citations

Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity

2002 • 50 citations

Relevance of MDMA ("ecstasy")-induced neurotoxicity to long-lasting psychomotor stimulation in mice

2003 • 48 citations

The effects of monoamine uptake inhibitors and methamphetamine on neostriatal 6-hydroxydopamine (6-OHDA) formation, short-term monoamine depletions and locomotor activity in the rat

1990 • 47 citations

Repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens:

1997 • 47 citations

Metabolism of 5-(Glutathion-S-yl)-.alpha.-methyldopamine following Intracerebroventricular Administration to Male Sprague-Dawley Rats

1995 • 46 citations

Methysergide potentiates the hyperactivity produced by MDMA in rats

1988 • 46 citations

Chronic treatment with supraphysiological levels of corticosterone enhances d-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse

2002 • 44 citations

Involvement of free radicals in MDMA-induced neurotoxicity in mice.

2001 • 43 citations

Differential effect of dietary selenium on the long-term neurotoxicity induced by MDMA in mice and rats

2003 • 41 citations

Major metabolites of(±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons

1991 • 41 citations

Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys

1989 • 41 citations

d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity

2002 • 39 citations

An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA

2002 • 39 citations

Effects of (±) 3,4-methylene–dioxymethamphetamine (ecstasy) on dopamine system function in humans

2002 • 39 citations

Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?

2002 • 39 citations

A study of the mechanism of insulin

1925 • 39 citations

Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine

1991 • 39 citations

Plasma Levels of Parent Compound and Metabolites after Doses of Either d-Fenfluramine or d-3,4-Methylenedioxymethamphetamine (MDMA) that Produce Long-Term Serotonergic Alterations

2003 • 38 citations

In vivo formation of aromatic hydroxylated metabolites of 3,4-(methylenedioxy)methamphetamine in the rat: Identification by ion trap tandem mass spectrometric (MS/MS and MS/MS/MS) techniques

1991 • 38 citations

Stimulant effects of 3,4-methylenedioxymethamphetamine in the nucleus accumbens of rat

1992 • 37 citations

Restraint as a stressor in mice:

2000 • 36 citations

Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity

1995 • 32 citations

MDMA: Historical Perspectives

1990 • 32 citations

Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice

2001 • 28 citations

Enkephalin contributes to the locomotor stimulating effects of 3,4‐methylenedioxy‐N‐methylamphetamine

2003 • 22 citations

Enhancement of Cocaine-Induced Hyperthermia Fails to Elicit Neurotoxicity11Reviewed through the Neurochemistry Section, James P. O’Callaghan, Ph.D., Section Editor.

1998 • 22 citations

Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent?

2003 • 20 citations

Altered prolactin response to M‐chlorophenylpiperazine in monkeys previously treated with 3,4‐methylenedioxymethamphetamine (MDMA) or fenfluramine

2002 • 15 citations

Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat

1989 • 13 citations

Is frequent dosing with ecstasy a risky business for dopamine-containing neurons?

2003 • 9 citations

The Interaction between the Central and Peripheral Nervous Systems in Mediating the Thermic Effect of Methamphetamine^a

1997 • 9 citations