Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1992 • 733 citations

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1987 • 526 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain.

1980 • 444 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons

1988 • 318 citations

Neurotoxicity of MDMA and Related Compounds: Anatomic Studies^a

1990 • 251 citations

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1991 • 222 citations

Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue

1986 • 206 citations

Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.

1991 • 186 citations

Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine

1987 • 184 citations

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.

1988 • 182 citations

5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

1993 • 137 citations

Persistent Effects of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) on Human Sleep

1993 • 116 citations

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) in rats

1994 • 111 citations

Ecstasy-fueled 'rave' parties become dances of death for English youths

1992 • 109 citations

Aminergic Metabolites in Cerebrospinal Fluid of Humans Previously Exposed to MDMA: Preliminary Observations^a

1990 • 106 citations

Adrenal and striatal tyrosine hydroxylase activity after methamphetamine.

1973 • 94 citations

Neuroendocrine and Mood Responses to Intravenous L-Tryptophan in 3,4-Methylenedioxymethamphetamine (MDMA) Users

1989 • 92 citations

Neurotoxicity of MDMA: Neurochemical Effects

1990 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: Evidence for the protective effect of chlormethiazole

1992 • 76 citations

Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine (“Ecstasy”)

1991 • 66 citations

A study of the mechanism of MDMA (‘Ecstasy’)‐induced neurotoxicity of 5‐HT neurones using chlormethiazole, dizocilpine and other protective compounds

1994 • 63 citations

L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats

1991 • 59 citations

Effect of chlormethiazole, dizocilpine and pentobarbital on harmaline-induced increase of cerebellar cyclic GMP and tremor

1993 • 58 citations

Effect of MK-801 on the decrease in tryptophan hydroxylase induced by methamphetamine and its methylenedioxy analog

1989 • 53 citations

Selective Accumulation of 3H-Serotonin by Nerve Terminals of Raphe Neurones: An Autoradiographic Study

1973 • 42 citations

The receptor antagonist, dextrorphan, prevents the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats

1989 • 35 citations

Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue

1991 • 35 citations

Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats

1991 • 23 citations

Chlormethiazole antagonises seizures induced by N-methyl-dl-aspartate without interacting with the NMDA receptor complex

1993 • 15 citations

Chlormethiazole attenuates the derangement of sensory evoked potential (SEP) induced by ICV administration of NMDA

1993 • 10 citations