The days and nights of cancer cells.

The Hallmarks of Cancer

2000 • 27,569 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Coordination of circadian timing in mammals

2002 • 4,132 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

1972 • 1,975 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Extensive and divergent circadian gene expression in liver and heart

2002 • 1,498 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

2002 • 1,216 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study

2001 • 1,113 citations

D-type cyclins

1995 • 978 citations

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

2002 • 881 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

1998 • 820 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Dec1 and Dec2 are regulators of the mammalian molecular clock

2002 • 654 citations

Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep

2003 • 649 citations

Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer

1997 • 646 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

A Long Twentieth Century of the Cell Cycle and Beyond

2000 • 602 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Effects of sleep and circadian rhythm on human circulating immune cells.

1997 • 584 citations

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

1999 • 558 citations

NPAS2: An Analog of Clock Operative in the Mammalian Forebrain

2001 • 555 citations

Role of nitric oxide in carcinogenesis and tumour progression

2001 • 552 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus

1990 • 523 citations

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

2001 • 508 citations

Increased Breast Cancer Risk among Women Who Work Predominantly at Night

2001 • 497 citations

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts

2000 • 478 citations

A unified view of the DNA-damage checkpoint

2002 • 458 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture.

1988 • 441 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

Host Circadian Clock as a Control Point in Tumor Progression

2002 • 403 citations

Regulation of cyclin-Cdk activity in mammalian cells

2002 • 392 citations

Joining the cell survival squad: an emerging role for protein kinase CK2

2002 • 384 citations

Circadian Expression of Clock Genes in Human Oral Mucosa and Skin

2001 • 375 citations

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism

2001 • 374 citations

Melatonin As a Free Radical Scavenger: Implications for Aging and Age‐Related Diseases^a

1994 • 350 citations

Effects of aging on central and peripheral mammalian clocks

2002 • 300 citations

Glucose Down-regulates Per1 and Per2mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts

2002 • 300 citations

Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.

1981 • 299 citations

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

2002 • 296 citations

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

2000 • 291 citations

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

2002 • 282 citations

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei

1999 • 282 citations

A role for CK2 in the Drosophila circadian oscillator

2003 • 276 citations

The F-box protein Slimb controls the levels of clock proteins Period and Timeless

2002 • 272 citations

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

2000 • 270 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

A Role for the Proteasome in the Light Response of the Timeless Clock Protein

1999 • 266 citations

RB kinases and RB-binding proteins: new points of view

1997 • 264 citations

Circadian-system alterations during cancer processes: A review

1997 • 254 citations

Circadian chronotherapy for human cancers

2001 • 249 citations

Activated Expression of the N- myc Gene in Human Neuroblastomas and Related Tumors

1984 • 246 citations

Mechanism of circadian variation in bone resorption

2002 • 246 citations

Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells.

1998 • 242 citations

Cancer chronotherapy: Principles, applications, and perspectives

2002 • 242 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation

1998 • 210 citations

Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.

1999 • 195 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

2002 • 179 citations

Melatonin: A Clock‐Output, A Clock‐Input

2003 • 177 citations

An Inherited Functional Circadian Clock in Zebrafish Embryos

2000 • 176 citations

Circadian Variation in the Expression of Cell-Cycle Proteins in Human Oral Epithelium

1999 • 174 citations

Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

2002 • 157 citations

RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.

2000 • 156 citations

Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium

1978 • 155 citations

Circadian rhythm of cellular proliferation in the human rectal mucosa

1991 • 154 citations

Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

2002 • 150 citations

Regulation of the Neurospora circadian clock by casein kinase II

2002 • 144 citations

Periodic Transcription: A Cycle within a Cycle

2003 • 141 citations

Acute fasting diminishes the circadian rhythm of biochemical markers of bone resorption

1999 • 134 citations

Light Induction of a Vertebrate Clock Gene Involves Signaling through Blue-Light Receptors and MAP Kinases

2002 • 133 citations

Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts

2001 • 131 citations

Contribution of the rest–activity circadian rhythm to quality of life in cancer patients

2002 • 129 citations

Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock

2002 • 125 citations

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects

2000 • 116 citations

Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae

1997 • 105 citations

Circadian rhythm in toxicities and tissue uptake of 1,2-diamminocyclohexane(trans-1)oxalatoplatinum(II) in mice.

1989 • 104 citations

Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators

2001 • 102 citations

Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications

2000 • 102 citations

Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy.

1993 • 101 citations

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

2003 • 101 citations

Circadian gating of S phase in human ovarian cancer.

1987 • 99 citations

Characterisation of the phosphorylation of β-catenin at the GSK-3 priming site Ser45

2002 • 97 citations

Time after time: inputs to and outputs from the mammalian circadian oscillators

2002 • 96 citations

Circadian clock and microarrays: mammalian genome gets rhythm

2002 • 91 citations

Circadian Transcription

2002 • 84 citations

Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133.

1997 • 82 citations

Oscillator control of cell division in Euglena: cyclic AMP oscillations mediate the phasing of the cell division cycle by the circadian clock

1993 • 80 citations

Circadian control of neurogenesis

2002 • 78 citations

Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status

2002 • 78 citations

Docetaxel chronopharmacology in mice.

1998 • 74 citations

Tumor-based rhythms of anticancer efficacy in experimental models

2002 • 69 citations

Differential Regulation of the N-myc Proto-Oncogene by RORα and RVR, Two Orphan Members of the Superfamily of Nuclear Hormone Receptors

1997 • 69 citations

DNA synthesis and ploidy in non-Hodgkin's lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling.

1993 • 68 citations

Transcriptional Regulation of Human Rev-erbα Gene Expression by the Orphan Nuclear Receptor Retinoic Acid-related Orphan Receptor α

2002 • 67 citations

Colony-forming unit-granulocyte-macrophage and DNA synthesis of human bone marrow are circadian stage-dependent and show covariation

1992 • 67 citations

Carbon Monoxide and Nitric Oxide: Interacting Messengers in Muscarinic Signaling to the Brain's Circadian Clock

2001 • 64 citations

The Circadian Rhythm for the Number and Sensitivity of Radiation-induced Apoptosis in the Crypts of Mouse Small Intestine

1990 • 60 citations

Regulation of N-myc Expression Is a Critical Event Controlling the Ability of Human Neuroblasts to Differentiate

1988 • 58 citations

Circadian rhythms in mitotic activity and ³H‐thymidine uptake in the duodenum: Effect of isoproterenol on the mitotic rhythm

1972 • 57 citations

Circadian variation of nitric oxide synthase activity in mouse tissue

2002 • 57 citations

A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte

1997 • 56 citations

The MYC dualism in growth and death

1999 • 50 citations

The Role of Controlled Proteolysis in Cell‐Cycle Regulation

1996 • 48 citations

Effect of constant light on DMBA mammary tumorigenesis in rats

2000 • 45 citations

Changes in the sleep–wake cycle architecture and cortical nitric oxide release during ageing in the rat

2003 • 42 citations

Diurnal variation in labelling index in human buccal epithelium

1993 • 36 citations

The Role of myc Oncogenes in Cell Growth and Differentiation

1990 • 34 citations

Diurnal variations in the expression of radiation-induced apoptosis.

1998 • 32 citations

Influence of the Circadian Rhythm in Cell Division on Radiation-Induced Mitotic Delay in Vivo

1982 • 28 citations

Resensitization due to Redistribution of Cells in the Phases of the Cell Cycle during Arbitrary Radiation Protocols

1996 • 24 citations

Importance of cell kinetics rhythmicity for the control of cell proliferation and carcinogenesis in rat liver (review).

1995 • 23 citations

Circadian regulation of CREB transcription factor in mouse esophagus

1998 • 23 citations

Effects of Cyclin‐Dependent Kinase Inhibitors on Transcription and Ocular Circadian Rhythm of Aplysia

1999 • 20 citations

Change in phase relations of circadian rhythms in cell proliferation induced by time-limited feeding in BALB/c X DBA/2F1 mice bearing a transplantable Harding-Passey tumor.

1983 • 17 citations

Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.

1995 • 16 citations

Circadian concepts in normal and neoplastic breast

2002 • 9 citations