Antiapoptotic Effects of Erythropoietin in Differentiated Neuroblastoma SH-SY5Y Cells Require Activation of Both the STAT5 and AKT Signaling Pathways

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The activation of Akt/PKB signaling pathway and cell survival

2005 • 1,806 citations

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

2000 • 1,409 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

2001 • 1,009 citations

In vivo evidence that erythropoietin protects neurons from ischemic damage

1998 • 931 citations

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

2001 • 930 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

2004 • 785 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

1999 • 716 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

2001 • 691 citations

Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

1996 • 658 citations

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

1997 • 654 citations

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

2001 • 649 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Emerging biological roles for erythropoietin in the nervous system

2005 • 508 citations

Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

1995 • 481 citations

Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model.

2002 • 455 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells

1993 • 424 citations

Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from anIn VitroModel

2002 • 380 citations

Erythropoietin and Erythropoietin Receptor in the Developing Human Central Nervous System

1998 • 358 citations

Erythropoietin Prevents Place Navigation Disability and Cortical Infarction in Rats with Permanent Occlusion of the Middle Cerebral Artery

1998 • 304 citations

The N-Terminal Domain of Janus Kinase 2 Is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor

2001 • 295 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo

1993 • 275 citations

Neurons and astrocytes express EPO mRNA: Oxygen-sensing mechanisms that involve the redox-state of the brain

2000 • 270 citations

Erythropoietin Receptor-mediated Inhibition of Exocytotic Glutamate Release Confers Neuroprotection during Chemical Ischemia

2001 • 253 citations

Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase‐mediated pathways

2003 • 243 citations

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction

1999 • 235 citations

A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury

2005 • 222 citations

Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

2002 • 206 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

1997 • 189 citations

Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐x_L expression

2002 • 186 citations

The Erythropoietin Receptor Cytosolic Juxtamembrane Domain Contains an Essential, Precisely Oriented, Hydrophobic Motif

2001 • 177 citations

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

1997 • 174 citations

Integrin-linked kinase is required for laminin-2–induced oligodendrocyte cell spreading and CNS myelination

2003 • 164 citations

A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction

2000 • 163 citations

Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8

2002 • 158 citations

Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity

1995 • 146 citations

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor

2003 • 144 citations

Insulin-stimulated Protein Kinase B Phosphorylation on Ser-473 Is Independent of Its Activity and Occurs through a Staurosporine-insensitive Kinase

2001 • 143 citations

Activation of Nuclear Factor κb and bcl-x Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of IκBα

2001 • 134 citations

Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

2001 • 132 citations

Activation of the Akt/FKHRL1 Pathway Mediates the Antiapoptotic Effects of Erythropoietin in Primary Human Erythroid Progenitors

2000 • 102 citations

The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors

1997 • 101 citations

Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis

1996 • 100 citations

Characterization of CPP32‐Like Protease Activity Following Apoptotic Challenge in SH‐SY5Y Neuroblastoma Cells

1997 • 96 citations

Acyl-CoA Synthetase 2 Overexpression Enhances Fatty Acid Internalization and Neurite Outgrowth

2004 • 87 citations

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.

1994 • 86 citations

Erythropoietin-induced Recruitment of Shc via a Receptor Phosphotyrosine-independent, Jak2-associated Pathway

1995 • 84 citations

Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases

2002 • 83 citations

DNA damage–induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway

2001 • 81 citations

Activation of the transcription factor NF-κB by the erythropoietin receptor

2001 • 70 citations

The prevention of the staurosporine‐induced apoptosis by Bcl‐X_L, but not by Bcl‐2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells

2001 • 66 citations

The Signal Transduction Pathway of Erythropoietin Involves Three Forms of Mitogen‐Activated Protein (MAP) Kinase in UT7 Erythroleukemia Cells

1995 • 66 citations

EPO receptor-mediated ERK kinase and NF-κB activation in erythropoietin-promoted differentiation of astrocytes

2004 • 61 citations

Astroglial cytoprotection by erythropoietin pre‐conditioning: implications for ischemic and degenerative CNS disorders

2005 • 57 citations

Chemosensitization by erythropoietin through inhibition of the NF-κB rescue pathway

2004 • 53 citations

Activation of Raf/ERK1/2 MAP kinase pathway is involved in GM-CSF-induced proliferation and survival but not in erythropoietin-induced differentiation of TF-1 cells

2001 • 53 citations

Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor

1992 • 48 citations

The SH2 Inositol 5-Phosphatase Ship1 Is Recruited in an SH2-dependent Manner to the Erythropoietin Receptor

2000 • 48 citations

NF-κB Family Proteins Participate in Multiple Steps of Hematopoiesis through Elimination of Reactive Oxygen Species

2004 • 40 citations

Tyrosine Residues within the Intracellular Domain of the Erythropoietin Receptor Mediate Activation of AP-1 Transcription Factors

1998 • 35 citations

Redundant and Selective Roles for Erythropoietin Receptor Tyrosines in Erythropoiesis In Vivo

1998 • 33 citations

Cytokine Receptor Common β Subunit-mediated STAT5 Activation Confers NF-κB Activation in Murine proB Cell Line Ba/F3 Cells

2002 • 31 citations

Activation of Nuclear Factor _KB in Human Neuroblastoma Cell Lines

1994 • 26 citations

Genetic Evidence for an Additional Factor Required for Erythropoietin-Induced Signal Transduction

1999 • 22 citations

Erythropoietin Induces Glycosylphosphatidylinositol Hydrolysis

1999 • 19 citations

Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts

1999 • 19 citations

Erythropoietin-mediated decrease of the redox-sensitive transcription factor NF-kB is inversely correlated with the hemoglobin level

2002 • 7 citations