Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Categorical Data Analysis

1991 • 9,374 citations

The Ki-67 protein: From the known and the unknown

2000 • 4,426 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.

2000 • 378 citations

PRC1

1998 • 359 citations

A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

1992 • 356 citations

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.

2000 • 321 citations

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

1989 • 302 citations

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

1998 • 288 citations

Microarray Analysis Identifies Interferon-Inducible Genes and Stat-1 as Major Transcriptional Targets of Human Papillomavirus Type 31

2000 • 285 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

1998 • 240 citations

The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis

1998 • 235 citations

Cdc7 is required throughout the yeast S phasetoactivatereplication origins

1998 • 224 citations

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

1999 • 207 citations

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

1998 • 178 citations

Evidence for a NIMA-like mitotic pathway in vertebrate cells

1995 • 174 citations

Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes

1999 • 164 citations

Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication

1996 • 151 citations

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

2000 • 143 citations

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

2000 • 129 citations

Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation

1997 • 129 citations

Binding of Human Minichromosome Maintenance Proteins with Histone H3

1996 • 127 citations

A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.

1994 • 120 citations

Cyclin-Dependent KinasesInitial Approaches to Exploit a Novel Therapeutic Target

1999 • 119 citations

Mechanisms and regulation of the degradation of cyclin B

1999 • 100 citations

Mutational Inactivation of Mitotic Checkpoint Genes, hsMAD2 and hBUB1, Is Rare in Sporadic Digestive Tract Cancers

1999 • 99 citations

Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis

1997 • 91 citations

Candidate Regulatory Sequence Elements for Cell Cycle-Dependent Transcription in Saccharomyces cerevisiae

1999 • 84 citations

The Kinetochore of Higher Eucaryotes: A Molecular View

1999 • 82 citations

The cell-cycle regulated transcription factor B-Myb is phosphorylated by Cyclin A/Cdk2 at sites that enhance its transactivation properties

1998 • 80 citations

Human Topoisomerase II Function, Tyrosine Phosphorylation and Cell Cycle Checkpoints

1998 • 77 citations

Identification and characterization of STK12/Aik2: a human gene related to <i>aurora</i> of Drosophila and yeast <i>IPL1</i>

1998 • 72 citations

Cdc20 associates with the kinase aurora2/Aik

1999 • 68 citations

The roles of DNA topoisomerase II during the cell cycle

1996 • 67 citations

Promoter analysis of co-regulated genes in the yeast genome

1999 • 64 citations

Selective Transcriptional Regulations in the Human Liver Cell by Hepatitis B Viral X Protein

2000 • 61 citations

Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs.

1999 • 61 citations

Cell-cycle regulation of B-Myb protein expression: specific phosphorylation during the S phase of the cell cycle.

1996 • 60 citations

Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.

1998 • 56 citations

The relationship of HsEg5 and the actin cytoskeleton to centrosome separation

1996 • 54 citations

Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer.

1997 • 50 citations

Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.

1996 • 50 citations

Nonuniform Microtubular Polarity Established by CHO1/MKLP1 Motor Protein Is Necessary for Process Formation of Podocytes

1998 • 46 citations

B-Myb: A Key Regulator of the Cell Cycle

1997 • 45 citations

CDC7 kinase complex as a molecular switch for DNA replication

1999 • 44 citations

Cell proliferation-associated nuclear antigen defined by antibody Ki-67: a new kind of cell cycle-maintaining proteins.

1995 • 43 citations

The NIMA kinase: A mitotic regulator in Aspergillus nidulans and vertebrate cells

1995 • 40 citations

MUTATIONS IN THE ATP‐BINDING DOMAIN AFFECT THE SUBCELLULAR DISTRIBUTION OF MITOTIC CENTROMERE‐ASSOCIATED KINESIN (MCAK)

1999 • 37 citations

Inhibitors of Topoisomerase II Delay Progress through Mitosis and Induce a Doubling of the DNA Content in CHO Cells

1995 • 35 citations

Topoisomerase II inhibition in mitosis produces numerical and structural chromosomal aberrations in human fibroblasts

1997 • 34 citations

Structural Requirements and Dynamics of Mitosin-Kinetochore Interaction in M Phase

1999 • 30 citations

Cloning and expression of human mitotic centromere-associated kinesin gene

1997 • 29 citations

MIB-1 (Ki-67) Immunostaining of Breast Cancer Cells in Cytologic Smears

1997 • 29 citations

Carboxyl terminus of mitosin is sufficient to confer spindle pole localization

1997 • 27 citations

HumanCDC23:cDNA Cloning, Mapping to 5q31, Genomic Structure, and Evaluation as a Candidate Tumor Suppressor Gene in Myeloid Leukemias

1998 • 25 citations

Pharmaceutical target discovery using Guilt-by-Association: schizophrenia and Parkinson's disease genes.

1999 • 14 citations