Disposition of azole antifungal agents. I. Nonlinearities in ketoconazole clearance and binding in rat liver.

A rapid and simple procedure for chronic cannulation of the rat jugular vein.

1974 • 646 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Ketoconazole

1982 • 270 citations

Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes

1987 • 242 citations

Clinical Pharmacokinetics of Ketoconazole

1988 • 218 citations

KETOCONAZOLE THERAPY FOR ADVANCED PROSTATE CANCER

1984 • 166 citations

Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver.

1984 • 123 citations

Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models

1979 • 119 citations

Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins

1987 • 117 citations

Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers

1986 • 115 citations

Ketoconazole in the Management of Precocious Puberty Not Responsive to LHRH-Analogue Therapy

1985 • 107 citations

The interaction of representative members from two classes of antimycotics—the azoles and the allylamines—with cytochromes P-450 in steroidogenic tissues and liver

1985 • 87 citations

The effect of ketoconazole on hepatic oxidative drug metabolism in the rat in vivo and in vitro.

1985 • 85 citations

Pharmacokinetics of Ketoconazole Administered Intravenously to Dogs and Orally as Tablet and Solution to Humans and Dogs

1986 • 53 citations

Ketoconazole. Use in the treatment of ectopic adrenocorticotropic hormone production and Cushing's syndrome in small-cell lung cancer

1985 • 52 citations

Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450

1987 • 47 citations

Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsornes

1987 • 42 citations

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose.

1990 • 38 citations

Determination of ketoconazole in the plasma, liver, lung and adrenal of the rat by high-performance liquid chromatography

1986 • 38 citations

Comparison of two azole antifungal drugs, ketoconazole and fluconazole, as modifiers of rat hepatic monooxygenase activity

1988 • 37 citations

The disposition and pharmacokinetics of ketoconazole in the rat.

1987 • 28 citations

Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics

1988 • 28 citations

In vivo and in vitro inhibition of hepatic microsomal drug metabolism by ketoconazole.

1985 • 24 citations

Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat.

1978 • 22 citations

Dose-dependent pharmacokinetics of cimetidine in the rat

1987 • 16 citations

The acute and subchronic effects of ketoconazole on hepatic microsomal monooxygenases in the rat

1988 • 8 citations