The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration.

1988 • 417 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.

1989 • 249 citations

Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen

1991 • 233 citations

Measurement of steroid hormone receptors in breast cancer patients on tamoxifen

1993 • 195 citations

Human breast cancer in the athymic nude mouse: Cystostatic effects of long-term antiestrogen therapy

1987 • 186 citations

Tamoxifen

1989 • 170 citations

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen

1982 • 169 citations

Tamoxifen and the isomers of 4-hydroxytamoxifen in tamoxifen-resistant tumors from breast cancer patients.

1992 • 144 citations

Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer.

1993 • 113 citations

Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells

1989 • 110 citations

Investigation of the Mechanism of Tamoxifen-Stimulated Breast Tumor Growth With Nonisomerizable Analogues of Tamoxifen and Metabolites

1993 • 92 citations

Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors.

1992 • 87 citations

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro.

1990 • 82 citations

Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells

1989 • 66 citations

Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-5H-benzocycloheptene, a nonisomerizable analog of tamoxifen. X-ray crystallographic studies

1986 • 50 citations

CURRENT CLINICAL ONCOLOGY

2003 • 44 citations

Nafoxidine–-an antiestrogen for the treatment of breast cancer

1976 • 43 citations

Nonisomerizable analogs of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes

1988 • 34 citations

Hormonal Treatment of Advanced Breast Cancer

1995 • 34 citations