Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.

1985 • 249 citations

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells.

1988 • 173 citations

Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line.

1987 • 137 citations

Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.

1986 • 108 citations

Tumor necrosis factor expression in human epithelial tumor cell lines.

1988 • 102 citations

A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.

1991 • 56 citations

Production of tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) by murine pre-B and B cell lymphomas.

1990 • 34 citations

Molecular control of tissue‐specific expression at the mouse TNF locus

1989 • 31 citations