Structural Instability of a Constitutively Active G Protein-coupled Receptor

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

1995 • 2,811 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

1989 • 519 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

The two-state model of receptor activation

1995 • 492 citations

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

1995 • 408 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

Rapid GDP release from Gsα in patients with gain and loss of endocrine function

1994 • 288 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.

1994 • 261 citations

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.

1992 • 260 citations

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

1994 • 249 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Amino and Carboxyl Terminal Modifications to Facilitate the Production and Purification of a G Protein-Coupled Receptor

1995 • 160 citations

Reverse intrinsic activity of antagonists on G protein-coupled receptors

1992 • 157 citations

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

1991 • 146 citations

Thrombin Receptor Activating Mutations

1996 • 102 citations

Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands

1993 • 84 citations

Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor

1994 • 56 citations

Amino Acid Side Chains That Define Muscarinic Receptor/G-protein Coupling

1996 • 54 citations

[31] Fluorescence assays for G-protein interactions

1994 • 10 citations