High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Molecular biology of dopamine receptors

1992 • 998 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Molecular cloning and expression of the gene for a human D1 dopamine receptor

1990 • 675 citations

Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications

1987 • 664 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

1989 • 519 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Germline mutations in the thyrotropin receptor gene cause non–autoimmune autosomal dominant hyperthyroidism

1994 • 376 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.

1991 • 359 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

1994 • 249 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.

1991 • 210 citations

Distribution of D5 dopamine receptor mRNA in rat brain

1992 • 176 citations

Reverse intrinsic activity of antagonists on G protein-coupled receptors

1992 • 157 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.

1994 • 150 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.

1991 • 125 citations

[2] Cellular responsiveness to hormones and neutrotransmitters: Conversion of [3H]Adenine to [3H]cAMP in cell monolayers, cell suspensions, and tissue slices

1991 • 124 citations

Dopamine Receptors and Transporters

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Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

Mutations in G protein-linked receptors: Novel insights on disease

1993 • 73 citations

Truncation of the extended carboxyl-terminal domain increases the expression and regulatory activity of the avian beta-adrenergic receptor

1991 • 64 citations

Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype.

1993 • 63 citations

Molecular Cloning, Stable Expression and Desensitization of the Human Dopamine D1B / D5 Receptor

1993 • 38 citations

Haloperidol increases prolactin release and cyclic AMP formation in vitro: inverse agonism at dopamine D2 receptors?

1993 • 36 citations

Active site-directed inactivation of constitutively active mutants of rhodopsin.

1994 • 24 citations