11 Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

The Anthracycline Antineoplastic Drugs

1981 • 794 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

The physiology of transferrin and transferrin receptors.

1987 • 586 citations

Iron and Susceptibility to Infectious Disease

1974 • 576 citations

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle.

1990 • 468 citations

The adverse effect of iron repletion on the course of certain infections.

1978 • 456 citations

Ribonucleotide Reductase—a Radical Enzyme

1983 • 423 citations

Free radical formation by antitumor quinones

1989 • 419 citations

Low molecular weight intracellular iron transport compounds

1977 • 389 citations

Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?

1989 • 385 citations

Iron metabolism in health and disease

1995 • 375 citations

Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria

1983 • 360 citations

Protective Effect of the Bispiperazinedione ICRF-187 against Doxorubicin-Induced Cardiac Toxicity in Women with Advanced Breast Cancer

1988 • 358 citations

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer.

1992 • 328 citations

Deferoxamine: a reversible S-phase inhibitor of human lymphocyte proliferation

1984 • 281 citations

DEFECT OF CELL-MEDIATED IMMUNITY IN PATIENTS WITH IRON-DEFICIENCY ANÆMIA

1972 • 259 citations

Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE

1977 • 254 citations

Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity.

1988 • 251 citations

Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.

1987 • 249 citations

Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro.

1990 • 247 citations

Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells

1976 • 242 citations

The Role of Iron in Bacterial Infections, with Special Consideration of Host-Tubercle Bacillus Interaction

1973 • 233 citations

Antioxidants in Therapy and Preventive Medicine

1990 • 215 citations

Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea

1986 • 211 citations

Effect of Iron Chelation Therapy on Recovery from Deep Coma in Children with Cerebral Malaria

1992 • 206 citations

Effects of a single course of deferoxamine in neuroblastoma patients.

1990 • 197 citations

Role of oxidants in ischemia/reperfusion-induced granulocyte infiltration

1990 • 193 citations

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1987 • 185 citations

1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE, AN ORALLY ACTIVE CHELATOR FOR TREATMENT OF IRON OVERLOAD

1987 • 183 citations

Anthracycline glycoside-membrane interactions

1984 • 172 citations

Antitumour Activity in a Series of bisDiketopiperazines

1969 • 159 citations

Malaria — Resurgence, Resistance, and Research

1983 • 149 citations

Iron-Chelating Therapy

1988 • 149 citations

Plasmodium Falciparum: Inhibition of in Vitro Growth by Desferrioxamine

1982 • 147 citations

Antineuroblastoma activity of desferoxamine in human cell lines.

1987 • 146 citations

Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents

1986 • 143 citations

Heart cells in culture: a model of myocardial iron overload and chelation.

1985 • 143 citations

The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction

1987 • 133 citations

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.

1993 • 130 citations

Deferoxamine inhibition of malaria is independent of host iron status.

1988 • 127 citations

Low molecular weight iron and the oxygen paradox in isolated rat hearts.

1992 • 127 citations

Bone Marrow Transplantation in Thalassemia

1991 • 124 citations

Comparison of the effectiveness of (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles.

1985 • 119 citations

Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide

1993 • 119 citations

Deferoxamine Therapy in High-Ferritin Diabetes

1989 • 112 citations

Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of Langerhans

1985 • 110 citations

Combined Treatment With Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice

1986 • 110 citations

A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor

1986 • 109 citations

Deferoxamine inhibition of human neuroblastoma viability and proliferation.

1988 • 108 citations

Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187).

1981 • 107 citations

Effect of iron and desferoxamine on cell growth andin vitro ferritin synthesis in human hepatoma cell lines

1990 • 107 citations

The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites.

1993 • 106 citations

Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.

1988 • 98 citations

Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

1986 • 98 citations

Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice

1992 • 97 citations

Production of leukemic blast growth factor by a human bladder carcinoma cell line

1985 • 96 citations

Oxygen Free-Radical Scavengers and Immune Destruction of Murine Islets in Allograft Rejection and Multiple Low-Dose Streptozocin-Induced Insulitis

1989 • 95 citations

Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.

1993 • 94 citations

Suppression of malaria infection by oxidant-sensitive host erythrocytes

1976 • 93 citations

Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines.

1992 • 92 citations

Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia [see comments]

1992 • 90 citations

Pharmacologic interventions for prevention of spinal cord injury caused by aortic crossclamping

1992 • 88 citations

Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man

1988 • 83 citations

Postischemic tissue injury by iron-mediated free radical lipid peroxidation

1985 • 83 citations

Antimalarial properties of orally active iron chelators

1988 • 79 citations

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine.

1978 • 77 citations

Role of iron in Trypanosoma cruzi infection of mice.

1984 • 77 citations

Desferrioxamine Suppresses Plasmodium falciparum in Aotus Monkeys

1987 • 75 citations

Iron loading of cultured cardiac myocytes modifies sarcolemmal structure and increases lysosomal fragility.

1993 • 75 citations

Biochemical determinants of adriamycin® toxicity in mouse liver, heart and intestine

1992 • 74 citations

Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture.

1993 • 74 citations

Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine

1992 • 72 citations

The Effect of Chronic Iron Deficiency on Some Biochemical Functions of the Human Hemopoietic Tissue

1970 • 71 citations

Reversed siderophores act as antimalarial agents.

1991 • 71 citations

A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum‘in vitro’: the unimportance of serum iron

1986 • 69 citations

Plasmodium vinckei: Suppression of mouse infections with desferrioxamine B

1985 • 65 citations

Deferoxamine, Cyclophosphamide, Etoposide, Carboplatin, and Thiotepa (D-CECaT)

1992 • 64 citations

Reduced susceptibility to lipid peroxidation in cold ischemie rabbit kidneys after addition of desferrioxamine, mannitol, or uric acid to the flush solution

1986 • 63 citations

Antimalarial activity of selected aromatic chelators.

1980 • 59 citations

Plasmodium falciparum: Inhibition in vitro with lactoferrin, desferriferrithiocin, and desferricrocin

1987 • 59 citations

The effect of N-alkyl modification on the antimalarial activity of 3- hydroxypyridin-4-one oral iron chelators

1991 • 58 citations

The effect of various chelating agents on the mobilization of iron from reticulocytes in the presence and absence of pyridoxal isonicotinoyl hydrazone

1984 • 57 citations

Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture

1991 • 57 citations

Organ Directed Toxicities of Anticancer Drugs

1988 • 55 citations

Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.

1988 • 55 citations

Decrease of myocardial infarct size with desferrioxamine: possible role of oxygen free radicals in its ameliorative effect

1992 • 54 citations

Stage-dependent effect of deferoxamine on growth of Plasmodium falciparum in vitro

1990 • 54 citations

Effect of iron loading on transmembrane potential, contraction, and automaticity of rat ventricular muscle cells in culture.

1989 • 53 citations

Mode of action of iron (III) chelators as antimalarials: I. Membrane permeation properties and cytotoxic activity

1993 • 52 citations

A study of the mechanism of action of pyridoxal isonicotinoyl hydrazone at the cellular level using reticulocytes loaded with non-heme 59Fe

1983 • 52 citations

Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.

1990 • 52 citations

NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation

1990 • 52 citations

Desferrioxamine Treatment Prevents Chronic Islet Allograft Damage

1986 • 52 citations

Iron Chelation as a Chemotherapeutic Strategy for Falciparum Malaria

1993 • 50 citations

Effect of supplementing cardioplegic solution with deferoxamine on reperfused human myocardium

1990 • 50 citations

Mechanism of antineuroblastoma activity of deferoxamine in vitro.

1988 • 49 citations

Deferoxamine prevents lipid peroxidation and attenuates reoxygenation injury in postischemic skeletal muscle

1993 • 49 citations

Prevention of doxorubicin-induced myocardial and haematological toxicities in rats by the iron chelator desferrioxamine

1992 • 49 citations

Modification of iron uptake and lipid peroxidation by hypoxia, ascorbic acid, and alpha-tocopherol in iron-loaded rat myocardial cell cultures.

1987 • 48 citations

Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria

1991 • 48 citations

Iron chelation in myocardial preservation after ischemia-reperfusion injury: The importance of pretreatment and toxicity

1992 • 48 citations

Iron chelators in medicine

1992 • 47 citations

Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice

1986 • 44 citations

Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation

1993 • 43 citations

Antimalarial effect of HBED and other phenolic and catecholic iron chelators

1989 • 43 citations

A transferrin-independent iron uptake activity in Plasmodium falciparum-infected and uninfected erythrocytes

1992 • 42 citations

Plasmodicidal effect of desferrioxamine B in human vivax or falciparum malaria from Thailand

1992 • 41 citations

Combination Iron Depletion Therapy

1989 • 40 citations

Selection of Hydroxypyridin-4-Ones for the Treatment of Iron Overload Using In Vitro and In Vivo Models

1988 • 40 citations

Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity.

1992 • 39 citations

Deferoxamine therapy in high-ferritin diabetes

1989 • 39 citations

Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart

1992 • 39 citations

A promising approach for improving the recovery of heart transplants. Prevention of free radical injury through iron chelation by deferoxamine.

1990 • 38 citations

Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis

1989 • 38 citations

Deferoxamine Attenuates Ischemia-Induced Reperfusion Injury in the Skin and Muscle of Myocutaneous Flaps in the Pig

1993 • 37 citations

Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia

1990 • 37 citations

Use of allopurinol and deferoxamine in cellular protection during ischemia

1992 • 35 citations

Malaria — Resurgence, Resistance, and Research

1983 • 34 citations

MODIFYING INTRACELLULAR REDOX BALANCE: AN APPROACH TO IMPROVING THERAPEUTIC INDEX

1985 • 33 citations

Iron loading modifies the fatty acid composition of cultured rat myocardial cells and liposomal vesicles: effect of ascorbate and alpha-tocopherol on myocardial lipid peroxidation.

1989 • 33 citations

The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate

1986 • 32 citations

No Effect of Deferoxamine Therapy on Glucose Homeostasis and Insulin Secretion in Individuals With NIDDM and Elevated Serum Ferritin

1993 • 32 citations

A promising approach for improving the recovery of heart transplants

1990 • 31 citations

Enhancement of the effectiveness of daunorubicin (NSC-82151) or adriamycin (NSC-123127) against early mouse L1210 leukemia with ICRF-159 (NSC-129943).

1975 • 29 citations

Synergistic inhibition of lymphoid tumor growth in vitro by combined treatment with the iron chelator deferoxamine and an immunoglobulin G monoclonal antibody against the transferrin receptor

1990 • 29 citations

14C-Desferrioxamine B: Uptake into erythrocytes infected withPlasmodium falciparum

1986 • 28 citations

Evidence of cytosolic iron release during post‐ischaemic reperfusion of isolated rat hearts Influence on spin‐trapping experiments with DMPO

1992 • 28 citations

Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity

1993 • 28 citations

Role of Iron in Anthracycline Action

1988 • 27 citations

Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig

1982 • 26 citations

Prevention of Postischemic Injury in Immature Intestine by Deferoxamine

1993 • 26 citations

Increased susceptibility to lipid peroxidation in rabbit kidneys: A consequence of warm ischaemia and subsequent reperfusion

1986 • 26 citations

The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat

1992 • 26 citations

D-CECaT

1993 • 25 citations

Maintenance of left ventricular function (90%) after twenty-four-hour heart preservation with deferoxamine

1992 • 25 citations

Adriamycin-iron catalysed phospholipid peroxidation: a reaction not involving reduced adriamycin or hydroxyl radicals

1983 • 25 citations

The role of iron in the cytotoxicity of tumor necrosis factor.

1993 • 24 citations

Effects of acute iron loading on contractility and spontaneous beating rate of cultured rat myocardial cells

1988 • 22 citations

Antimalarial activity of selected aromatic chelators. IV. Cation uptake by Plasmodium falciparum in the presence of oxines and siderochromes.

1986 • 22 citations

Structural requirements for anthracycline-induced cardiotoxicity and antitumor effects

1989 • 21 citations

Comparison of New Iron Chelating Agents in the Prevention of Ischemia/Reperfusion Injury: A Swine Model of Heart-Lung Transplantation

1992 • 20 citations

Cell cycle specific effects of deferoxamine on human and murine hematopoietic progenitor cells.

1988 • 20 citations

The in vitro response of human tumour cells to desferrioxamine is growth medium dependent

1993 • 19 citations

The effect of liposome-entrapped desferrioxamine onLeishmania donovani in vitro

1989 • 19 citations

Ultrastructural changes in rat lungs after 48 h cold storage with and without reperfusion.

1990 • 19 citations

Deferoxamine, an iron chelator, reduces myocardial injury and free radical generation in isolated neonatal rabbit hearts subjected to global ischaemia-reperfusion

1992 • 17 citations

Desferrioxamine treatment prevents chronic islet allograft damage

1986 • 17 citations

No effect of deferoxamine therapy on glucose homeostasis and insulin secretion in individuals with NIDDM and elevated serum ferritin

1993 • 17 citations

Age-related differences in cardiac susceptibility to ischemia/reperfusion injury

1992 • 16 citations

In vivo antimalarial action of a lipophilic iron (III) chelator: Suppression of plasmodium vinckei infection by reversed siderophore

1993 • 15 citations

Malaria pigment and extracellular iron

1993 • 14 citations

Allopurinol and deferoxamine improve canine lung preservation.

1990 • 13 citations

Progress in iron research

1995 • 13 citations

THE RED CELL AND THE MALARIAL PARASITE

1980 • 13 citations

Failure of Iron Chelators to Protect Against Cerebral Infarction in Hypoxia-Ischemia

1993 • 12 citations

Pulmonary peptides, norepinephrine and endocrine cells in monocrotaline pulmonary hypertension.

1991 • 9 citations

Influence of Selenium on Lipid Peroxidation and Cardiac Functions in Chronically Adriamycin-Treated Rats

1990 • 7 citations

Are Oxygen Radicals Responsible for the Acute Cardiotoxicity of Doxorubicin?

1990 • 7 citations

Differential effects of liposome-entrapped desferrioxamine on proliferation and erythroid differentiation of murine erythroleukemic Friend cells

1989 • 6 citations

The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells

1994 • 6 citations

Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2-mercaptoproprionyl glycine.

1993 • 5 citations

Bone marrow transplantation in thalassemia. The experience of Pesaro.

1989 • 3 citations

Deleted Work

1955 • 0 citations