Double in situ hybridization in combination with digital image analysis: A new approach to study interphase chromosome topography

Localization of heterochromatin in human chromosomes

1971 • 965 citations

An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.

1987 • 850 citations

Cloning of human satellite III DNA: different components are on different chromosomes

1979 • 470 citations

A glimpse at chromosomal order

1987 • 423 citations

Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction

1988 • 279 citations

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments

1982 • 271 citations

Three-dimensional chromatin distribution in neuroblastoma nuclei shown by confocal scanning laser microscopy

1985 • 253 citations

Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories

1985 • 231 citations

Direct covalent mercuration of nucleotides and polynucleotides

1975 • 197 citations

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes

1988 • 177 citations

Optical fluorescence microscopy in three dimensions: microtomoscopy

1985 • 149 citations

Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments

1982 • 147 citations

Reconstructing 3-D light-microscopic images by digital image processing

1985 • 129 citations

Bi-color detection of two target DNAs by non-radioactive in situ hybridization

1986 • 116 citations

Organization of a repetitive human 1.8 kb KpnI sequence localized in the heterochromatin of chromosome 15

1985 • 116 citations

Direct evidence for the non-random localization of mammalian chromosomes in the interphase nucleus

1986 • 100 citations

A non-radioactivein situhybridization method based on mercurated nucleic acid probes and sulfhydryl-hapten ligands

1986 • 85 citations

Attraction between centric heterochromatin of human chromosomes

1975 • 83 citations

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes

1984 • 83 citations

Active Nucleolus Organizers Are Precisely Positioned in Adult Central Nervous System Cells but Not in Neuroectodermal Tumor Cells

1984 • 56 citations

Chromosomal constitution of nucleolus-associated chromatin in man

1976 • 47 citations

Mercurated nucleic acid probes, a new principle for non-radioactive in situ hybridization

1987 • 38 citations

The position of chromosomes at metaphase in human fibroblasts and their DNA synthesis behaviour

1969 • 34 citations

Position of chromosomes in the human interphase nucleus

1982 • 31 citations

Non-random association of trypsin-banded human acrocentric chromosomes

1977 • 26 citations

Epithelial character and morphologic diversity of cell cultures from human amniotic fluids examined by immunofluorescence microscopy and gel electrophoresis of cytoskeletal proteins

1983 • 25 citations

Nonrandom arrangement of human chromatin: topography of disomic markers X, Y, and 1h+

1973 • 21 citations

Segmentation of cell nuclei in tissue section analysis.

1983 • 20 citations

Patterns of association in the human metaphase complement: Ring analysis and estimation of associativity of specific chromosome regions

1978 • 20 citations

Quantitative studies on the arrangement of human metaphase chromosomes. IX. Arrangement of chromosomes with and without spindle apparatus

1982 • 16 citations

Helical conformation of dense fibres from mammalian spermatozoa

1980 • 8 citations

Random position of human heterochromatin-bearing chromosomes in first and third mitoses of lymphocyte cultures

1980 • 3 citations