Insulin-stimulated Protein Kinase B Phosphorylation on Ser-473 Is Independent of Its Activity and Occurs through a Staurosporine-insensitive Kinase

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1999 • 555 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

2000 • 302 citations

90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

1999 • 254 citations

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1999 • 216 citations

The Structure-Based Design of ATP-Site Directed Protein Kinase Inhibitors

1999 • 172 citations

Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

1999 • 113 citations

7-Hydroxystaurosporine (UCN-01) Induces Apoptosis in Human Colon Carcinoma and Leukemia Cells Independently of p53

1997 • 89 citations

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

2000 • 87 citations

Activation of protein kinase C subtypes α, γ, δ, ϵ, ζ, and η by tumor-promoting and nontumor-promoting agents

1997 • 87 citations

Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase.

1998 • 29 citations

Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.

1998 • 27 citations

Homogeneous Purification of Human Recombinant GST–Akt/PKB from Sf9 Cells

1999 • 23 citations