Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Death and the cell

1986 • 616 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

1986 • 380 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast

1981 • 341 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Apoptosis Biochemical events and relevance to cancer chemotherapy

1992 • 238 citations

Ionophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes

1991 • 235 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage.

1993 • 181 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Endogenous nuclease. Properties and effects on transcribed genes in chromatin.

1982 • 159 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Chondroclasts and endothelial cells collaborate in the process of cartilage resorption

1992 • 126 citations

Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes.

1988 • 120 citations

A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation.

1970 • 99 citations

Apoptosis—programmed cell death: a role in the aging process?

1992 • 95 citations

Apoptosis or Programmed Cell Death

1991 • 79 citations

Sutural Morphogenesis in the Mouse Calvaria: The Role of Apoptosis

1985 • 72 citations

Cytotoxic T lymphocytes induce different types of DNA damage in target cells of different origins.

1991 • 55 citations

Genome Digestion Is a Dispensable Consequence of Physiological Cell Death Mediated by Cytotoxic Τ Lymphocytes

1992 • 51 citations

Asynchronous development of the rat colon

1991 • 17 citations

The regulatory role of zinc in apoptosis in human tumour cell lines

1992 • 5 citations