Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

The Phagosome Proteome

2001 • 680 citations

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

2000 • 564 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)

2000 • 418 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

Mechanisms of antigen uptake for presentation

1996 • 354 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Defective Antigen Processing in GILT-Free Mice

2001 • 260 citations

Antigen processing for amateurs and professionals

1998 • 255 citations

Proteases involved in MHC dass II antigen presentation

1999 • 235 citations

Role for Cathepsin F in Invariant Chain Processing and Major Histocompatibility Complex Class II Peptide Loading by Macrophages

2000 • 229 citations

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

2000 • 221 citations

Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing

2001 • 217 citations

Lysosomal Enzyme Trafficking between Phagosomes, Endosomes, and Lysosomes in J774 Macrophages

1998 • 201 citations

The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation

1999 • 179 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Endosomal proteolysis and MHC class II function

1998 • 168 citations

Antigen processing in the endocytic compartment

2001 • 156 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Different fates of phagocytosed particles after delivery into macrophage lysosomes.

1996 • 131 citations

Neutrophils Process Exogenous Bacteria Via an Alternate Class I MHC Processing Pathway for Presentation of Peptides to T Lymphocytes

2001 • 130 citations

Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosomes

1997 • 130 citations

A closer look at proteolysis and MHC-class-II-restricted antigen presentation

2002 • 127 citations

Phagosomes Are Fully Competent Antigen-Processing Organelles That Mediate the Formation of Peptide:Class II MHC Complexes

1999 • 87 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.

1993 • 82 citations

The p41 isoform of invariant chain is a chaperone for cathepsin L

2001 • 76 citations

Mechanistic Studies on the Inactivation of Papain by Epoxysuccinyl Inhibitors

1996 • 69 citations

Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcγ receptors

2001 • 53 citations

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties

1999 • 20 citations