Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 848 citations

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1997 • 782 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

1990 • 497 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

1997 • 480 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1993 • 433 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

1992 • 412 citations

Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)

1996 • 373 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

1992 • 319 citations

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

1992 • 297 citations

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1991 • 285 citations

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.

1992 • 273 citations

ADAMTS-1 Protein Anchors at the Extracellular Matrix through the Thrombospondin Type I Motifs and Its Spacing Region

1998 • 225 citations

Monoclonal antibodies that specifically recognize neoepitope sequences generated by ‘aggrecanase’ and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1995 • 212 citations

Cell-mediated Catabolism of Aggrecan

1995 • 197 citations

Families of metalloendopeptidases and their relationships

1992 • 195 citations

Prediction of the Coding Sequences of Unidentified Human Genes. VII. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1997 • 193 citations

Snake venom metalloproteinases: Structure, function and relationship to the ADAMs family of proteins

1996 • 184 citations

Optimization of DNase I Removal of Contaminating DNA from RNA for Use in Quantitative RNA-PCR

1996 • 177 citations

A PCR-based method for high stringency screening of DNA libraries

1993 • 171 citations

INTEGRIN EXPRESSION BY HUMAN ARTICULAR CHONDROCYTES

1992 • 165 citations

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

1991 • 164 citations

cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components

1997 • 163 citations

Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.

1992 • 163 citations

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1993 • 161 citations

Prediction of the Coding Sequences of Unidentified Human Genes. X. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 160 citations

Function of Disintegrin-like/Cysteine-rich Domains of Atrolysin A

1997 • 141 citations

Generation and Characterization of Aggrecanase

1999 • 131 citations

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1992 • 131 citations

Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis.

1992 • 120 citations

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373–A374 in the interglobular domain of cartilage aggrecan

1994 • 118 citations

Transformation of Cultured Drosophila melanogaster Cells with a Dominant Selectable Marker

1985 • 93 citations

ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats

1999 • 86 citations

The Exon/Intron Organization and Chromosomal Mapping of the Mouse ADAMTS-1 Gene Encoding an ADAM Family Protein with TSP Motifs

1997 • 68 citations

Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains

1991 • 63 citations

Expression, Activation, and Processing of the Recombinant Snake Venom Metalloproteinase, Pro-Atrolysin E

1996 • 63 citations

Pathways of aggrecan processing in joint tissues Implications for disease mechanism and monitoring

1995 • 58 citations

Cleavage of Native Cartilage Aggrecan by Neutrophil Collagenase (MMP-8) Is Distinct from Endogenous Cleavage by Aggrecanase

1997 • 49 citations

Catabolism of Aggrecan by Explant Cultures of Human Articular Cartilage in the Presence of Retinoic Acid

1995 • 32 citations

A Serine Proteinase Inactivator Inhibits Chondrocyte-Mediated Cartilage Proteoglycan Breakdown Occurring in Response to Proinflammatory Cytokines

1998 • 16 citations