Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1993 • 433 citations

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

1992 • 412 citations

Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis

1993 • 325 citations

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

1992 • 297 citations

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1991 • 285 citations

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.

1992 • 273 citations

Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids

1991 • 262 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

1990 • 249 citations

Monoclonal antibodies that specifically recognize neoepitope sequences generated by ‘aggrecanase’ and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1995 • 212 citations

Fragments of human fibroblast collagenase. Purification and characterization

1989 • 210 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

Cell-mediated Catabolism of Aggrecan

1995 • 197 citations

The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis

1990 • 197 citations

Mechanism of catabolism of aggrecan by articular cartilage

1992 • 182 citations

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

1991 • 164 citations

The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis

1993 • 163 citations

Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus

1994 • 163 citations

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1993 • 161 citations

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1992 • 131 citations

Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate.

1989 • 125 citations

Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradation

1993 • 123 citations

Cloning and sequencing of mouse collagenase cDNA Divergence of mouse and rat collagenases from the other mammalian collagenases

1992 • 120 citations

Fragmentation of human polymorphonuclear-leucocyte collagenase

1993 • 118 citations

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373–A374 in the interglobular domain of cartilage aggrecan

1994 • 118 citations

Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein

1989 • 104 citations

Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

1995 • 102 citations

Direct Evidence for Active Metalloproteinases Mediating Matrix Degradation in Interleukin 1-Stimulated Human Articular Cartilage

1993 • 98 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 97 citations

Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage.

1992 • 90 citations

Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography

1986 • 72 citations

Inactivation of human plasma α₁‐proteinase inhibitor by human PMN leucocyte collagenase

1990 • 65 citations

Proteolysis of human native and oxidised α1-proteinase inhibitor by matrulysin and stromelysin

1994 • 54 citations

Molecular cloning of chicken aggrecan. Structural analyses

1992 • 42 citations

Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan

1994 • 38 citations

Cleavage of proteoglycan aggregate by leucocyte elastase

1992 • 35 citations

Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

1993 • 33 citations

Cited By (0)

Loading...