The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy

2002 • 1,549 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

IL-1 is required for tumor invasiveness and angiogenesis

2003 • 986 citations

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

1998 • 956 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

2004 • 813 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

2005 • 687 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

2002 • 478 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 347 citations

RETRACTED: Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

2003 • 323 citations

Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

1987 • 279 citations

The role of interleukin 1 in growth and metastasis of human cancer xenografts.

2006 • 273 citations

A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function

2002 • 204 citations

Processing, shedding, and endocytosis of membrane type 1‐matrix metalloproteinase (MT1‐MMP)

2004 • 189 citations

Neutralization of interleukin-1β in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling

2001 • 141 citations

Human Leydig Cells and Sertoli Cells Are Producers of Interleukins-1 and -6¹

1997 • 126 citations

Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences

1993 • 123 citations

c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism

2004 • 97 citations

Angiogenesis is an early event in the generation of myc-induced lymphomas

2000 • 90 citations

Activation of the Myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA

2000 • 87 citations

Human Leydig Cells and Sertoli Cells Are Producers of Interleukins-1 and -6

1997 • 82 citations

Reversible Kinetic Analysis of Myc Targets In vivo Provides Novel Insights into Myc-Mediated Tumorigenesis

2006 • 78 citations

An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.

2000 • 78 citations

Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation

2004 • 74 citations

Interleukin-1β Regulates Angiopoietin-1 Expression in Human Endothelial Cells

2004 • 62 citations

Down‐regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells

1999 • 60 citations

Differential control of VEGF synthesis and secretion in human glioma cells by IL‐1 and EGF

1999 • 54 citations

Bcl-xL gain of function and p19ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

2006 • 51 citations

In vivo Assessment of RAS-Dependent Maintenance of Tumor Angiogenesis by Real-time Magnetic Resonance Imaging

2005 • 51 citations

VEGF-A AND -C but not -B mediate increased vascular permeability in preserved lung grafts1

2002 • 51 citations

Proinflammatory Cytokines Upregulate mRNA Expression and Secretion of Vascular Endothelial Growth Factor in Cultured Human Airway Smooth Muscle Cells

2005 • 47 citations

Influence of cytokines on matrix metalloproteinases produced by fibroblasts cultured in monolayer and collagen gels.

2001 • 38 citations

Induction of Manganese Superoxide Dismutase in Human Dermal Fibroblasts

2002 • 38 citations

Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids

2005 • 32 citations

Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts

2003 • 31 citations

Divergent Expression Patterns for Hypoxia-Inducible Factor-1β and Aryl Hydrocarbon Receptor Nuclear Transporter-2 in Developing Kidney

2004 • 27 citations

Interleukin-1β stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes

2004 • 25 citations