Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Inflammation and cancer

2002 • 14,174 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

2004 • 2,481 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy

2002 • 1,549 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Strategies for MMP inhibition in cancer: innovations for the post-trial era

2002 • 1,309 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Imaging of angiogenesis: from microscope to clinic

2003 • 990 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

VEGF is required for growth and survival in neonatal mice

1999 • 901 citations

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

2002 • 892 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

2002 • 594 citations

Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin

2003 • 543 citations

PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor

2001 • 542 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

2003 • 527 citations

Assignment of the Vascular Endothelial Growth Factor Gene to Human Chromosome 6p21.3

1996 • 473 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression

2000 • 423 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

VEGF: an update on biological and therapeutic aspects

2000 • 372 citations

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis

2002 • 372 citations

Structural basis for the anticoagulant activity of the thrombin–thrombomodulin complex

2000 • 310 citations

Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance

1999 • 274 citations

TACE is required for the activation of the EGFR by TGF-α in tumors

2003 • 270 citations

Isoforms of Vascular Endothelial Growth Factor Act in a Coordinate Fashion To Recruit and Expand Tumor Vasculature

2000 • 262 citations

ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

2003 • 255 citations

Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect

1997 • 240 citations

Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation

2003 • 228 citations

Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D

2003 • 195 citations

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

2003 • 184 citations

Formation of endothelial cell networks

2000 • 164 citations

Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation

2002 • 162 citations

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

2003 • 160 citations

Progesterone Regulates Proliferation of Endothelial Cells

1999 • 141 citations

ErbB4 and Its Isoforms Selective Regulation of Growth Factor Responses by Naturally Occurring Receptor Variants

2000 • 139 citations

Lie detection and language comprehension

2000 • 124 citations

Cell cell interactions in vascular development

2001 • 119 citations

Disulfide Structure of the Heparin Binding Domain in Vascular Endothelial Growth Factor: Characterization of Posttranslational Modifications in VEGF

1997 • 71 citations

Inhibition of Vascular Permeability Factor (Vascular Endothelial Growth Factor) with Antipeptide Antibodies

1993 • 61 citations

Vascular development and patterning: making the right choices

2003 • 55 citations