Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

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1989 • 6,734 citations

AJCC Cancer Staging Manual

2002 • 6,356 citations

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

2004 • 3,727 citations

AJCC Cancer Staging Manual. 6th ed

2002 • 2,374 citations

Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype

2007 • 1,940 citations

Concordance among Gene-Expression–Based Predictors for Breast Cancer

2006 • 1,336 citations

Epigenetic therapy of cancer: past, present and future

2006 • 1,271 citations

Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype

2008 • 1,177 citations

The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy

1998 • 973 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas

2007 • 605 citations

Risk Factors for Breast Cancer According to Estrogen and Progesterone Receptor Status

2004 • 514 citations

Role of the Ras-Association Domain Family 1 Tumor Suppressor Gene in Human Cancers

2005 • 392 citations

Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer

1992 • 387 citations

Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen

2004 • 308 citations

Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.

2000 • 291 citations

DNA Methylation as a Therapeutic Target in Cancer

2007 • 281 citations

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.

2001 • 245 citations

DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma

2003 • 243 citations

Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.

2001 • 212 citations

Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E‐cadherin and catenin expression and microsatellite instability

2003 • 202 citations

Loss of Estrogen Receptor Signaling Triggers Epigenetic Silencing of Downstream Targets in Breast Cancer

2004 • 185 citations

Epigenetic Information and Estrogen Receptor Alpha Expression in Breast Cancer

2006 • 184 citations

The role for NES1 serine protease as a novel tumor suppressor.

1998 • 173 citations

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

2005 • 171 citations

Breast Cancer DNA Methylation Profiles in Cancer Cells and Tumor Stroma: Association with HER-2/neu Status in Primary Breast Cancer

2006 • 168 citations

Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines.

1990 • 162 citations

A Role for the RASSF1A Tumor Suppressor in the Regulation of Tubulin Polymerization and Genomic Stability

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Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression.

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Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulators

2005 • 154 citations

Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma.

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Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers

2001 • 147 citations

Nonrandom Distribution of Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors

2004 • 141 citations

Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung

2004 • 139 citations

Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma.

2001 • 138 citations

Hypermethylation in Histologically Distinct Classes of Breast Cancer

2004 • 114 citations

Novel Mechanisms of Resistance to Endocrine Therapy: Genomic and Nongenomic Considerations

2006 • 111 citations

Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case–control and a case–case comparison

2006 • 106 citations

Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.

2003 • 104 citations

DNA hypermethylation in breast cancer and its association with clinicopathological features

2005 • 104 citations

Reduction of E-cadherin expression is associated with non-lobular breast carcinomas of basal-like and triple negative phenotype

2007 • 102 citations

Clinical trials with retinoids for breast cancer chemoprevention

2006 • 101 citations

Rates for Breast Cancer Characteristics by Estrogen and Progesterone Receptor Status in the Major Racial/Ethnic Groups

2002 • 97 citations

Estrogen Receptors: Role in Breast Cancer

2006 • 93 citations

Nutrition and breast cancer

2003 • 92 citations

Identification of the E1A-Regulated Transcription Factor p120E4F as an Interacting Partner of the RASSF1A Candidate Tumor Suppressor Gene

2004 • 79 citations

RASSF1A Suppresses the c-Jun-NH2-Kinase Pathway and Inhibits Cell Cycle Progression

2005 • 79 citations

Hormone receptors do not predict the HER2/neu status in all age groups of women with an operable breast cancer

2005 • 60 citations

Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis

2006 • 58 citations

DNA Methylation as a Therapeutic Target in Cancer

2008 • 56 citations

Breast cancer risk factors according to joint estrogen receptor and progesterone receptor status

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The receptor expression pattern in ductal carcinoma in situ predicts recurrence

2006 • 39 citations

Fluctuation of HER2 Expression in Breast Carcinomas during the Menstrual Cycle

1999 • 28 citations

Evaluation of oestrogen and progesterone receptor status in HER-2 positive breast carcinomas and correlation with outcome

2006 • 24 citations