Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E‐cadherin and catenin expression and microsatellite instability

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Wnt signaling and cancer

2000 • 3,215 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 541 citations

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

1999 • 530 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

2000 • 462 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

2001 • 453 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 448 citations

E-cadherin—catenin cell—cell adhesion complex and human cancer

2000 • 448 citations

Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.

1993 • 398 citations

Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression

2000 • 387 citations

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis

1997 • 341 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinomain situ

1997 • 299 citations

Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation

1999 • 294 citations

Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.

2000 • 291 citations

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.

2001 • 245 citations

Abnormalities of the APC/β-catenin pathway in endometrial cancer

2002 • 236 citations

Catenins, Wnt signaling and cancer

2000 • 227 citations

Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast

2001 • 226 citations

Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene

2001 • 223 citations

Semiautomated assessment of loss of heterozygosity and replication error in tumors.

1996 • 222 citations

A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities.

2000 • 212 citations

Distinct methylation pattern and microsatellite instability in sporadic gastric cancer

1999 • 173 citations

Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.

2000 • 162 citations

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

2001 • 151 citations

E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas.

1999 • 149 citations

Wnt signaling in breast cancer: have we come full circle?

2001 • 148 citations

Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers

2001 • 147 citations

E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.

2000 • 146 citations

Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas.

1995 • 141 citations

Somatic Mutations of the APC Gene in Primary Breast Cancers

2000 • 111 citations

No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas.

1996 • 109 citations

Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer

1999 • 102 citations

Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer

2002 • 92 citations

CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk

2001 • 90 citations

Involvement of adenomatous polyposis coli (APC)/β-catenin signalling in human breast cancer

2000 • 89 citations

E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas

1999 • 83 citations

Association of the −160 C → a promoter polymorphism of E‐cadherin gene with gastric carcinoma risk

2002 • 79 citations

Single‐nucleotide polymorphism in the E‐cadherin gene promoter modifies the risk of prostate cancer

2002 • 60 citations

Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype.

2002 • 60 citations

CDH1 c‐160a promotor polymorphism is not associated with risk of stomach cancer

2002 • 56 citations

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high‐frequency microsatellite instability

2001 • 55 citations

Low frequency of E-cadherinalterations in familial breast cancer

2001 • 49 citations

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.

1994 • 37 citations

Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene

2000 • 36 citations

Decreased E-cadherin augments β-catenin nuclear localization: Studies in breast cancer cell lines

2001 • 32 citations

DNA methylation and gastrointestinal malignancies: functional consequences and clinical implications

2000 • 27 citations

Catenins, Wnt signaling and cancer

2000 • 21 citations