Hormone receptors do not predict the HER2/neu status in all age groups of women with an operable breast cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer

2004 • 1,134 citations

Letrozole Is More Effective Neoadjuvant Endocrine Therapy Than Tamoxifen for ErbB-1– and/or ErbB-2–Positive, Estrogen Receptor–Positive Primary Breast Cancer: Evidence From a Phase III Randomized Trial

2001 • 1,075 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

1992 • 769 citations

Quantitative Association Between HER-2/neu and Steroid Hormone Receptors in Hormone Receptor-Positive Primary Breast Cancer

2003 • 584 citations

Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer.

1994 • 573 citations

HER-2 Testing in Breast Cancer Using Parallel Tissue-Based Methods

2004 • 446 citations

The addition of Herceptin (humanized anti-HER2 antibody) to first-line chemotherapy for HER2-overexpressing metastatic breast cancer (HER2+ MBC) markedly increases anti-cancer activity: A randomized, multinational controlled phase II trial.

1998 • 366 citations

Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: results of a prospective Southwest Oncology Group study.

1992 • 360 citations

Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers.

1998 • 336 citations

Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer.

1995 • 312 citations

Breast cancer outcome and predictors of outcome: are there age differentials?

1994 • 268 citations

The prognostic value of c-erbB2 in primary breast carcinomas: A study on 942 cases

1995 • 183 citations

HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer.

1989 • 150 citations

Relationship between oestrogen-receptor content and histological grade in human primary breast tumours

1978 • 137 citations

HER-2/neu Overexpression and Response to Oophorectomy Plus Tamoxifen Adjuvant Therapy in Estrogen Receptor-Positive Premenopausal Women With Operable Breast Cancer

2003 • 135 citations

Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up.

1989 • 115 citations

Do we need HER‐2/neu testing for all patients with primary breast carcinoma?

2003 • 102 citations

Correlation of primary breast cancer histopathology and estrogen receptor content

1981 • 101 citations

Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor.

1992 • 100 citations

Preferential HER‐2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer

2004 • 65 citations

Association between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related

2005 • 63 citations

Immunohistochemical analysis of p53 and HER-2/neu proteins in human tumors.

1991 • 63 citations

Genetic evolution of breast cancers III: Age-dependent variations in the correlations between biological indicators of prognosis

1995 • 35 citations

Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades

1993 • 24 citations

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

1982 • 15 citations